Understanding psoriasis: Role of miRNAs (Review)

Orăsan, Remus Ioan

doi:10.3892/br.2018.1146

Cited by 31 publications

(41 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miRNA-21, -31, -146), but on the other hand, others revealed downregulation of miRNA (e.g. miRNA-145-5p, -197) in patients with active psoriasis [37,38,39]. A recent study by Wu et al showed new miRNA in psoriasis, which happens to be one of the most investigated…”

Section: State Of Knowledgementioning

confidence: 99%

Environmental risk factors and epigenetic alternations in psoriasis

Roszkiewicz¹,

Dopytalska²,

Szymańska³

et al. 2020

Ann Agric Environ Med.

View full text Add to dashboard Cite

Introduction and objective. Psoriasis isa quite common, chronic and immune-mediated skin disorder. The prevalence of psoriasis differs in various countries, but it is said to affect 2% of the world's population in general. Psoriasis has many different clinical features but all lesions have the same characteristic: erythema, thickening and scale, although other clinical features are also connected, such as psoriatic arthritis, obesity and metabolic syndrome. All of these may lead to conditions impairing the quality of life. This review is an attempt to summarize recent data regarding environmental factors, together with epigenetic markers and processes playing an important role in psoriasis. State of knowledge. Many different environmental factors play a role in genetically predisposed patients. This is causes epigenetic alternations which may be a linking part in the whole process. Many studies have indicated a connection between psoriasis and various genes and antigens. The presence of HLA-Cw6 is common as well a strong link between its presence and the onset of psoriasis being observed. The main alternations are DNA methylation, histone's modifications and the role of microRNA. Excessive reaction is usually not present without a triggering factor. Environmental factors are mostly rated, such as drugs, life style and habits (smoking, alcohol), diet, physical trauma (skin injury provoking Koebner phenomenon), stress, microorganism and infections. Conclusions. The correlation between pathogenesis of psoriasis and environmental risk factors, together with epigenetic alternations still require more investigation. Education about diet habits, nutrition, weight loss and healthy lifestyle seems to be important during the treatment of psoriasis.

show abstract

Section: State Of Knowledgementioning

confidence: 99%

Environmental risk factors and epigenetic alternations in psoriasis

Roszkiewicz¹,

Dopytalska²,

Szymańska³

et al. 2020

Ann Agric Environ Med.

View full text Add to dashboard Cite

show abstract

“…These mature transcripts regulate expression of their target genes at post-transcriptional level. Dysregulation in the expression of these transcripts contribute in the pathogenesis of psoriasis [ 22 ]. Fig.…”

Section: Mirnas and Psoriasismentioning

confidence: 99%

The eminent roles of ncRNAs in the pathogenesis of psoriasis

Ghafouri‐Fard

Eghtedarian

Taheri

et al. 2020

Non-coding RNA Research

View full text Add to dashboard Cite

Psoriasis is a chronic immune-related disorder in which both genetic and environmental parameters are involved. Recent studies have demonstrated dysregulation of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the peripheral blood or skin lesions of patients with psoriasis. While a number of lncRNAs such as MEG3, AL162231.4 and NONHSAT044111 have been down-regulated in the course of psoriasis, others including PRINS, MIR31HG, RP6‐65G23.1, MSX2P1, SLC6A14-1:1, NR_003062 have been up-regulated. Moreover, expressions of several miRNAs have been dysregulated in this disorder. Among dysregulated miRNAs are miR-126, miR-143, miR-19a and miR-155 whose diagnostic roles in the psoriasis have also been assessed. Dysregulated non-coding RNAs in this disorder participate in the regulation of chemokine signaling pathway and immune response, control of epidermal development and skin barrier as well as modulation of function of certain subsets of T cells. Besides, these transcripts possibly regulate activity of NF-κΒ, mTOR, MAPK and JAK-STAT signaling pathways. Besides, expression levels of circRNAs have been decreased in the psoriasis lesions. Massive alterations in the levels of lncRNAs and miRNAs in the psoriasis lesions or peripheral blood of affected individuals show participation of these transcripts in the pathogenesis of this disorder.

show abstract

“…The upregulation of miR-155, together with miR-146a, is consistently associated with this 'classically' activated MP profile; however, the immunomodulatory role of miR-146a in the MP response has not been clearly defined [41][42][43][44][45][46]. Regardless, due to their typical expression profile in degenerations, miR-155 and miR-146a have been suggested as therapeutic targets in numerous inflammation-associated conditions, such as systemic lupus erythematosus [47], psoriasis [48], rheumatoid arthritis and neurodegenerative conditions including, amyotrophic lateral sclerosis (ALS), Alzheimer's disease and AMD [24,26,31,[49][50][51].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of microRNA-155 Protects Retinal Function Through Attenuation of Inflammation in Retinal Degeneration

et al. 2020

View full text Add to dashboard Cite

Although extensively investigated in inflammatory conditions, the role of pro-inflammatory microRNAs (miRNAs), miR-155 and miR-146a, has not been well-studied in retinal degenerative diseases. We therefore aimed to explore the role and regulation of these miRNA in the degenerating retina, with a focus on miR-155. C57BL/6J mice were subjected to photo-oxidative damage for up to 5 days to induce focal retinal degeneration. MiR-155 expression was quantified by qRT-PCR in whole retina, serum, and small-medium extracellular vesicles (s-mEVs), and a PrimeFlow™ assay was used to identify localisation of miR-155 in retinal cells. Constitutive miR-155 knockout (KO) mice and miR-155 and miR-146a inhibitors were utilised to determine the role of these miRNA in the degenerating retina. Electroretinography was employed as a measure of retinal function, while histological quantification of TUNEL+ and IBA1+ positive cells was used to quantify photoreceptor cell death and infiltrating immune cells, respectively. Upregulation of miR-155 was detected in retinal tissue, serum and s-mEVs in response to photo-oxidative damage, localising to the nucleus of a subset of retinal ganglion cells and glial cells and in the cytoplasm of photoreceptors. Inhibition of miR-155 showed increased function from negative controls and a less pathological pattern of IBA1+ cell localisation and morphology at 5 days photo-oxidative damage. While neither dim-reared nor damaged miR-155 KO animals showed retinal histological difference from controls, following photo-oxidative damage, miR-155 KO mice showed increased a-wave relative to controls. We therefore consider miR-155 to be associated with the inflammatory response of the retina in response to photoreceptor-specific degeneration.

show abstract

Understanding psoriasis: Role of miRNAs (Review)

Cited by 31 publications

References 44 publications

Environmental risk factors and epigenetic alternations in psoriasis

Environmental risk factors and epigenetic alternations in psoriasis

The eminent roles of ncRNAs in the pathogenesis of psoriasis

Inhibition of microRNA-155 Protects Retinal Function Through Attenuation of Inflammation in Retinal Degeneration

Contact Info

Product

Resources

About