Understanding the complex chromatin dynamics in primary human neutrophils during PMA-induced NET formation
Brandi Atteberry,
Benjamin P. Berman,
Theresa K. Kelly
et al.
Abstract:BackgroundPrimary human neutrophils play a pivotal role in innate immunity, mainly through the formation of neutrophil extracellular traps (NETs) in a process known as NETosis. This cell-death pathway is crucial for combating infections but is also implicated in many inflammatory diseases, such as sepsis, systemic lupus erythematosus, and rheumatoid arthritis.MethodsThe study presented here investigates chromatin dynamics during NET formation by stimulating primary human neutrophils with phorbol 12-myristate 1… Show more
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