Understanding the Differences Between Gastroparesis and Gastroparesis-Like Syndrome: Filling a GaPing Hole?

Gotfried, Jonathan; Schey, Ron

doi:10.1007/s10620-017-4702-z

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…It is also important to be able to differentiate gastroparesis from gastroparesis like syndrome (GLS). These two diseases are incredibly difficult to differentiate by gastric emptying testing (GET) alone [ 11 ]. Recent investigations into distinguishing the two based on interstitial cells of Cajal (ICC) loss and fibrosis of the pylorus (with gastroparesis patients having worse features comparatively) are proving as better methods to determine which patients would benefit from more invasive therapies [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Gastric Electrical Stimulation for Gastroparesis: US/European Comparison

Burlen

Runnels²,

Mehta

et al. 2018

Gastroenterol Res

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BackgroundGastric electrical stimulation (GES) is used in both the US and Europe, but little research has investigated the demographics of gastroparesis patients receiving GES by geographic location.MethodsWe compared data from 380 patients, 296 female and 84 males, mean age 42 years, 246 idiopathic (ID), 107 diabetic (DM), and 27 post-surgical (PS). The statistical significance was calculated by Chi-square test and a P-value obtained for ID, DM, and PS. The statistical significance was calculated by Fischer exact test and a P-value obtained comparing male vs. female.ResultsEuropean centers had 61 GES patients compared to 319 from the US. In Europe, 100% of patients had gastric emptying test (GET) values available; in the US, it was 75% of patients. European centers had more DM patients (59%) than the US (22%), and a smaller proportion of ID patients (25%) than the US (72%). There was a statistical difference between the causes of gastroparesis in the patients receiving GES (P-value < 0.00001). There was also significant difference in the gender of the patients receiving GES, with a greater proportion of women in the US (P value = 0.0023).ConclusionsComparing GES in US vs. Europe demonstrated significant differences in gastroparesis demographics and percentage of patients with GET data. After analyzing the previously discussed results and reviewing recent updates in evidence-based medicine guidelines, the discrepancy and variance in patient populations in the US and Europe emphasizes the need for a database that allows better analysis and treatment of gastroparesis patients worldwide including stimulation therapies.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Gastric Electrical Stimulation for Gastroparesis: US/European Comparison

Burlen

Runnels²,

Mehta

et al. 2018

Gastroenterol Res

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“…Studies have demonstrated that significantly more fibrosis is present in the pylorus in GP patients, compared with patients with GLS, that demonstrates that fibrosis is a main pathogenic factor in the process of delayed gastric emptying in GP patients [40]. Furthermore, in a retrospective analysis, pyloroplasty in GP patients was associated with improvement in symptoms and improved gastric emptying in 83% of patients [42].…”

Section: Gastroparesis-like Syndromementioning

confidence: 94%

“…There is still debate over the definition and the differences between GLS and IGP. Gastric empting as diagnosed by nuclear scintigraphy may modify its clinical outcome in time and is considerable related to modifications by systemic processes (glycemic values, weight loss, etc) and medications [40].…”

Section: Gastroparesis-like Syndromementioning

confidence: 99%

“…Abdominal vagal afferents that identify potentially emetogenic substances in the lumen also terminate in this zone. Results from a wide variety of experiments show that the nucleus tractus solitarius connects to the emetic central pattern generator which is located in the retrofacial nucleus of the reticular formation playing a key role in the progression of various stimuli that will finally have the effect of emesis induction [37,38,40,41]. It controls respiratory groups that coordinate the muscular movements involved in retching and vomiting.…”

Section: Gastroparesis-like Syndromementioning

confidence: 99%

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Functional Emesis

Popa

Chiarioni

David

et al. 2019

JGLD

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Background: Emesis is an essential survival response, because consumption of food is a key element in the survival behavior and the act of feeding can expose the majority of internal organs to toxins, altered food, viruses, bacteria or fungi. The relationship between visceral or vestibular stimuli and the anatomical structures of the brain-gut axis explain the modulation of the gastrointestinal response. We aimed to review comprehensively the current knowledge on emesis occurring in the disorders of brain-gut interaction (DBGI), i.e. functional conditions presenting with emesis. Methods: PubMed, Cochrane Library, EMBASE and WILEY databases were screened for relevant publications from the last 20 years regarding brain-gut disorders manifesting emesis. We included in the search also idiopathic gastroparesis, as a condition paralleling the postprandial distress syndrome. Results: We critically analyzed 2 articles about chronic nausea and vomiting syndrome, 9 articles about cyclic vomiting syndrome, 9 articles about cannabinoid hyperemesis, 10 articles about idiopathic gastroparesis and 6 articles about gastroparesis like-syndrome. Contradictory results regarding the implication of environmental factors in the development of emesis in DBGI demonstrate that the underlying pathogenesis is still not completely understood.

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