Understanding the Elevated Lethality of COVID-19 in Liver Transplant Recipients: Does Immunosuppression Management Matter? Results from a Brazilian Multicentric Historical Cohort

Boin, Ilka FSF; Riccetto, Eduardo; Genzini, Tércio; Santos, Regina G; Moreira, Luíz Felipe Pinho; Pinto, Laura Cristina Machado; Garcia, José Huygens Parente; Stucchi, Raquel SB; Perales, Simone Reges; Zanaga, Letícia Pisoni; Silva, Renato F.; Silva, R.; Haddad, Luciana Bertocco de Paiva; D’Albuquerque, Luiz Augusto Carneiro; DeAlmeida, Mary; Watanabe, André Luís Conde; Peixoto, Gustavo S; Melo, Cristina Carvalho de; Bezerra, Renata Ferreira; Tefilli, Nertan Luiz; Halpern, Márcia; Godoy, Maira Silva; Nogara, Marcelo Augusto Scheidemantel; Mancero, Jorge Marcelo Padilla; Noujaim, Huda Maria; Rangel, Érika Bevilaqua; Ataíde, Elaine Cristina de

doi:10.1016/j.transproceed.2023.05.007

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Effects Of the Pandemic On Patients With Liver Disease1

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2023

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“…In a study exploring the effects of reducing/stopping immunosuppressant drugs in post-transplantation patients, discontinuation of tacrolimus was associated with an increase in the number of deaths; dose reduction of the agents reviewed did not affect outcomes. 59 …”

Section: Effects Of the Pandemic On Patients With Liver Diseasementioning

confidence: 99%

COVID-19 and the Liver: A Complex and Evolving Picture

Taylor-Robinson,

Morgan

2023

HMER

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Although the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily attacks the respiratory system, other organs, such as the liver, are also affected. In this overview, the effects of SARS-CoV-2 infection on the liver in both healthy people and in those with pre-existing liver disease are documented; the relationship between coronavirus disease 19 (COVID-19) vaccination and liver injury is examined; the mechanism of SARS-CoV-2-associated liver injury is explored; and the long-term consequences of COVID-19 are delineated, both in people with and without pre-existing liver disease.

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Section: Effects Of the Pandemic On Patients With Liver Diseasementioning

confidence: 99%