As an important energy replacement block in China, the tight conglomerate oilfields in the Mahu area are difficult to develop and are characterized by strong heterogeneity, large horizontal stress differences, and undeveloped natural fractures. However, new development processes including temporary blocking diversion and large section-multiple clusters have been implemented on the oilfields in the past few years. In 2020, two adjacent horizontal wells in the MD well area experienced a poor fracturing development effect compared with the earlier wells in this area. Analysis suggests that the main reasons are water sensitivity of the reservoir, insufficient fracturing scale, and/or interference from the adjacent old wells. To ameliorate the problem, this study presents an experimental study of multiple temporary plugging and refracturing technology in long horizontal well sections, in combination with electromagnetic and microseismic monitoring. Results from the study show a great difference between the two monitoring techniques, which is attributed to their different detection principles. Interestingly, the combination of the two approaches provides a greater performance than either approach alone. As the fracturing fluid flow diversion is based on temporary plugging diversion and electromagnetic monitoring of fracturing fluid is advantageous in temporary plugging diversion monitoring, both approaches require further research and development to address complex situations such as multiple temporary plugging and refracturing in long intervals of adjacent older wells.