Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease

Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma

“…Alternatively, a 24 h OA administration to donor-derived hiPSC differentiated into HLC can be exploited to study NAFLD progression. 61 Taking the ethical issues aside, using different donors could be relatively straightforward to evaluate the sex- or estrogen-dependent differences in these models. However, HLC derived from hiPSC are mostly used to model the early-stage events of NAFLD.…”