Une course contre la montre

Iseni, Frédéric; Tournier, Jean‐Nicolas

doi:10.1051/medsci/2020124

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…The spectacular progress in synthetic biology and reverse genetics methods over the last 20 years also increases the risks associated with gain-of-function experiments: it is now possible to assemble a viral genome in about ten days from different DNA fragments synthesized on the basis of sequences from one or more wild virus genomes and to obtain a "new" virus in less than a month (Zeng et al 2016;Thao et al 2020;Iseni and Tournier 2020).…”

Section: Genetic Manipulations Of Viruses and Gain-of-function Experimentioning

confidence: 99%

Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

et al. 2021

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SARS-CoV-2 is a new human coronavirus (CoV), which emerged in China in late 2019 and is responsible for the global COVID-19 pandemic that caused more than 97 million infections and 2 million deaths in 12 months. Understanding the origin of this virus is an important issue, and it is necessary to determine the mechanisms of viral dissemination in order to contain future epidemics. Based on phylogenetic inferences, sequence analysis and structure–function relationships of coronavirus proteins, informed by the knowledge currently available on the virus, we discuss the different scenarios on the origin—natural or synthetic—of the virus. The data currently available are not sufficient to firmly assert whether SARS-CoV2 results from a zoonotic emergence or from an accidental escape of a laboratory strain. This question needs to be solved because it has important consequences on the risk/benefit balance of our interactions with ecosystems, on intensive breeding of wild and domestic animals, on some laboratory practices and on scientific policy and biosafety regulations. Regardless of COVID-19 origin, studying the evolution of the molecular mechanisms involved in the emergence of pandemic viruses is essential to develop therapeutic and vaccine strategies and to prevent future zoonoses. This article is a translation and update of a French article published in Médecine/Sciences, August/September 2020 (10.1051/medsci/2020123).

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Section: Genetic Manipulations Of Viruses and Gain-of-function Experimentioning

confidence: 99%

Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

et al. 2021

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“…developed the hypothesis that the virus might have arisen from serial passages, and accidental escape from the lab(Sirotkin et Sirotkin 2020).The spectacular progress in synthetic biology and reverse genetics methods over the last 20 years also increases the risks associated with gain of function experiments: it is now possible to assemble a viral genome in about ten days from different DNA fragments synthesized on the basis of sequences from one or more wild virus genomes and to obtain a "new" virus in less than a month(Zeng et al 2016;Thao et al 2020;Iseni et Tournier 2020).…”

mentioning

confidence: 99%

Retrouver les origines du SARS-CoV-2 dans les phylogénies de coronavirus

et al. 2020

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Le SARS-CoV-2 est un nouveau coronavirus (CoV) humain. Il a émergé en Chine fin 2019 et est responsable de la pandémie mondiale de Covid-19 qui a causé plus de 540 000 décès en six mois. La compréhension de l’origine de ce virus est une question importante et il est nécessaire de déterminer les mécanismes de sa dissémination afin de pouvoir se prémunir de nouvelles épidémies. En nous fondant sur des inférences phylogénétiques, l’analyse des séquences et les relations structure-fonction des protéines de coronavirus, éclairées par les connaissances actuellement disponibles, nous discutons les différents scénarios évoqués pour rendre compte de l’origine - naturelle ou synthétique - du virus.

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