Une fuite rénale de phosphates complexe…

Intravenous iron-induced hypophosphatemia and kidney stone disease

“…Inflammatory bowel diseases (IBD), especially Crohn's disease, and short bowel syndrome are risk factors for hyperoxaluria and urolithiasis. The present case series shows that in patients who underwent bowel resection, treatment of iron deficiency with FCM and treatment of FCM-associated hypophosphatemia with calcitriol or phosphate could represent additional risk factors for symptomatic kidney stone disease in predisposed patients ( Daude et al, 2021 ).…”

“…A distinctive feature of urolithiasis associated with FCM-induced hypophosphatemia could be calculus formation as collecting duct plugs at the tip of the kidney papillae ( Daude et al, 2021 ). Accordingly, sequential CT imaging showed that after stone passage no papillary calcifications remained.…”

“…High FGF23, hypophosphatemia, hyperphosphaturia, which are hallmarks of XLH and TIO, can also be caused by certain intravenous iron formulations – in particular ferric carboxymaltose (FCM), iron polymaltose or rarely high doses of saccharated iron oxide ( Schaefer et al, 2020 ). High FGF23 in IV iron-induced hypophosphatemia is also associated with low 1,25-(OH) 2 -Vitamin D and secondary hyperparathyroidism ( Wolf et al, 2020 ; Daude et al, 2021 ). Therefore, high doses of calcitriol have been used to treat IV iron-induced hypophosphatemia ( Vasquez-Rios et al, 2021 ; Anand and Schmid, 2017 ).…”