Unexpected pleural finding after a fall

Giraudo, Chiara; Fraia, Anna Sara; Bellini, Alice; Fortarezza, Francesco; Rea, Federico; Calabrese, Fiorella

doi:10.1016/s1470-2045(19)30505-4

Cited by 2 publications

(2 citation statements)

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“…The second case shows an extremely rare variant of mesothelioma, the localized subtype. This was previously reported by our group as Clinical Picture in a peer-reviewed journal [ 13 ]. The LMM shares the same morphological, immunophenotypic, and ultrastructural characteristics of diffuse forms and is similarly classified into epithelioid, biphasic, and sarcomatoid [ 14 ].…”

Section: Discussionmentioning

confidence: 55%

Diagnostic Challenges in Epithelioid Pleural Mesothelioma: Case Series with Support from Electron Microscopy

et al. 2021

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The histological diagnosis of pleural epithelioid mesothelioma can be difficult in the case of rare variants or in the definition of neoplasm origin in patients with previous or concomitant tumours. Currently, several immunohistochemical reactions are available in the surgical pathologist’s armamentarium that allow us to obtain a more sensitive and specific diagnosis of malignant pleural mesothelioma. However, in some cases, the final interpretation remains inconclusive. Historically, ultrastructural examination has represented a useful tool for the definition of the mesothelial nature of neoplastic cells due to their peculiar morphological characteristics. The recent international guidelines for pathological diagnosis of pleural mesothelioma suggest the use of electron microscopy when the immunohistochemical reactions are equivocal or when further support of a diagnosis of mesothelioma is needed. This paper presents three cases of pleural epithelioid mesothelioma whose diagnoses were finally supported by ultrastructural examination.

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Section: Discussionmentioning

confidence: 55%

Diagnostic Challenges in Epithelioid Pleural Mesothelioma: Case Series with Support from Electron Microscopy

et al. 2021

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“…In mesothelioma's initial stages, symptoms tend to be non‐specific, meaning it is often diagnosed at a late stage 4 . However, occasionally, mesothelioma is diagnosed at an asymptomatic stage after an incidental finding 5 . Once disease is advanced, the symptom burden is severe, including breathlessness, chest wall pain, weight loss, sweating and fatigue, with severity increasing and sometimes proving difficult to palliate 6 …”

Section: Introductionmentioning

confidence: 99%

What are the psychological effects of mesothelioma on patients and their carers? A scoping review

et al. 2020

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Objective: Despite recent advances in research, malignant mesothelioma remains an incurable and devastating disease, typically bringing shock and emotional distress to patients and carers. Little research has addressed the psychological impact on either group. This scoping review examines the current state of evidence on the psychological effects of mesothelioma on patients and carers, and identifies areas for further research. Methods: We searched PubMed, PsychINFO, CINAHL, the Cochrane Library and Web of Science for English-language peer-reviewed research articles published 1981 to 2019 reporting studies focussing on the psychological effects of mesothelioma on patients and carers. Following data extraction and quality appraisal, reflexive thematic analysis was used to identify themes. Results: Seventeen articles met the inclusion criteria. Carers' experiences were generally amalgamated with patients'. Three themes were developed. The Passing of Time included the importance of timing of interventions; delays in the medical journey; awareness of different time-phases in mesothelioma; and uncertainty/certainty. Dealing with Difficult Feelings reflected ubiquitous negative emotions, feelings about identity and states of being and associated coping strategies. Craving Good Communication covered issues related to sharing of information and to positive/negative aspects of communication. Conclusions: Though limited, the evidence indicates that mesothelioma, with its high symptom-burden, incurability, rarity and asbestos-related causation, leads to complex and interrelating psychological effects on patients and carers. These effects are both negative and positive. The sparse literature gives a partial picture and demonstrates an urgent need for more nuanced research. Studies exploring the experiences of specific groups are recommended, with particular attention required to carers.

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Unexpected pleural finding after a fall

Cited by 2 publications

References 0 publications

Diagnostic Challenges in Epithelioid Pleural Mesothelioma: Case Series with Support from Electron Microscopy

Diagnostic Challenges in Epithelioid Pleural Mesothelioma: Case Series with Support from Electron Microscopy

What are the psychological effects of mesothelioma on patients and their carers? A scoping review

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