Unexpected successful fertilization in vitro of oocytes retrieved 60 hours after human chorionic gonadotrophin injection

Al-Mizyen, E.; Balet, R.; Lower, A.M.; Wilson, Clare; McClure, A; Shawaf, T. Al; Grudzinskas, J. G.

doi:10.1093/humrep/13.4.1020

Cited by 7 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, no patient ovulated prematurely due to the extension of interval between hCG and oocyte retrieval ( 188 ). Interestingly, a case report has suggested that mature oocytes can be retrieved following a prolonged interval of ~60 hours after hCG administration ( 189 ). Successful fertilization and embryo transfer were performed, although no subsequent pregnancy ensued, suggesting that the interval between hCG and oocyte retrieval can be extended from the standard 36 hours in many patients without causing ovulation.…”

Section: Endocrine Requirements For Oocyte Maturation and Ovulationmentioning

confidence: 99%

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

2018

View full text Add to dashboard Cite

Infertility affects one in six of the population and increasingly couples require treatment with assisted reproductive techniques. In vitro fertilization (IVF) treatment is most commonly conducted using exogenous FSH to induce follicular growth and human chorionic gonadotropin (hCG) to induce final oocyte maturation. However, hCG may cause the potentially life-threatening iatrogenic complication “ovarian hyperstimulation syndrome” (OHSS), which can cause considerable morbidity and, rarely, even mortality in otherwise healthy women. The use of GnRH agonists (GnRHas) has been pioneered during the last two decades to provide a safer option to induce final oocyte maturation. More recently, the neuropeptide kisspeptin, a hypothalamic regulator of GnRH release, has been investigated as a novel inductor of oocyte maturation. The hormonal stimulus used to induce oocyte maturation has a major impact on the success (retrieval of oocytes and chance of implantation) and safety (risk of OHSS) of IVF treatment. This review aims to appraise experimental and clinical data of hormonal approaches used to induce final oocyte maturation by hCG, GnRHa, both GnRHa and hCG administered in combination, recombinant LH, or kisspeptin. We also examine evidence for the timing of administration of the inductor of final oocyte maturation in relationship to parameters of follicular growth and the subsequent interval to oocyte retrieval. In summary, we review data on the efficacy and safety of the major hormonal approaches used to induce final oocyte maturation in clinical practice, as well as some novel approaches that may offer fresh alternatives in future.

show abstract

Section: Endocrine Requirements For Oocyte Maturation and Ovulationmentioning

confidence: 99%

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

2018

View full text Add to dashboard Cite

show abstract

“…However, several studies [2,[12][13][14] had shown that ideal ART performance can be obtained when oocyte retrieval was done more than 36 h (up to 39 h) after hCG priming. Successful fertilization in vitro of oocytes retrieved 60 h after hCG injection was reported in 1998 [15]. The prolonged luteinization-to-oocyte retrieval increased the production of oocytes with fully expanded cumulus, which may reflect oocyte maturation, then researchers presumed that the subsequent proportion of oocytes proceeding to fertilization and cleavage also increased, implying that a longer interval may improve gamete quality by allowing more optimal in vivo maturation.…”

Section: Introductionmentioning

confidence: 99%

The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

Wang

Zhang

Wang

et al. 2011

J Assist Reprod Genet

View full text Add to dashboard Cite

Objective To evaluate the relationship between different hCG priming-to-oocyte retrieval intervals and assisted reproductive technology (ART) outcome. Methods We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index, Chinese biomedicine (CBM) literature database, and Chinese Journal Full-text Database for randomized controlled trials (RCTs) published up to November 2010. Data was extracted from the studies by two independent reviewers. Statistical analysis was performed with Cochrane Collaboration's Review Manager (RevMan) 5.0.2. From extracted data, Risk Ratio (RR) with 95% confidence interval (CI) was calculated. Results 5 RCTs totaling 895 participants were included. Oocyte maturation rate was higher in the long interval group compared with short interval group (RR, 0.67; 95% CI, 0.62-0.73). There were no significant difference between the two groups with regard to fertilization rate (RR, 0.99; 95% CI, 0.94-1.04), implantation rate (RR, 0.91; 95% CI, 0.40-2.04), and pregnancy rate (RR, 0.79; 95% CI, 0.58-1.08). Conclusion The percentage of mature (MII) oocytes can be increased by prolonging the interval between hCG priming and oocyte retrieval. The prolonged interval could not increase the fertilization rate, implantation rate, and pregnancy rate. Although there was evidence to confirm the results, they still need to be confirmed by large-sample, multicenter, randomized controlled trials. The time interval dependent mechanisms responsible for ART performance need to be elucidated.

show abstract

Delayed oocyte retrieval

Sharif

2021

Assisted Reproduction Techniques

View full text Add to dashboard Cite

Unexpected successful fertilization in vitro of oocytes retrieved 60 hours after human chorionic gonadotrophin injection

Cited by 7 publications

References 6 publications

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

Delayed oocyte retrieval

Contact Info

Product

Resources

About