Uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy with low systemic toxicity

Abstract

Resulting from their versatile functionality, nanomaterials with low systemic toxicity have offered high-performance diagnostic and therapeutic capabilities. Here, we designed and synthesized uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy. Through a classical Stöber method and a hydrothermal process, well-defined MgSiO3 hollow spheres were prepared in a facile route with inexpensive inhesion. Compared with routinely used mesoporous silica nanoparticles, our MgSiO3 hollow spheres with larger void space and mesoporous shell endowed the structures with a much higher storage capacity of guest molecules (2140 mg DOX g(-1)) and a much more sustained release of anticancer drugs. In detail, the release property and therapeutic efficacy of DOX-loaded nanoparticles were evaluated in vitro and in vivo. In vitro experiments revealed that these nanoparticles were mostly accumulated in lysosome, which facilitated continual drug release and efficient cancer cell destruction. We further demonstrated that these DOX-loaded nanoparticles could effectively suppress tumor growth compared to free DOX in vivo, as DOX-loaded-nanoparticle-treated mice survived over 15 days without obvious detectable tumor growth. Otherwise, long-term toxicity study was also evaluated, indicating their overall safety and great potential in biomedical applications.

Achieving accelerated osteogenic differentiation via novel magnesium silicate hollow spheres

“…[28][29][30][31][32] Remarkably, these materials possessed the same mineral elements as those of previously reported magnesium silicate-based bioceramics and composite scaffolds. [28][29][30][31][32] Remarkably, these materials possessed the same mineral elements as those of previously reported magnesium silicate-based bioceramics and composite scaffolds.…”

“…28 Cell culture MC3T3-E1 pre-osteoblasts of mice were obtained from the Chinese Academy of Sciences Cell Bank (Shanghai, China). 28 Cell culture MC3T3-E1 pre-osteoblasts of mice were obtained from the Chinese Academy of Sciences Cell Bank (Shanghai, China).…”

High drug-loading nanomedicines: progress, current status, and prospects

“…Similarly, Wang et al synthesized hollow mesoporous magnesium silicate NPs via a facile template-etching route. 48 These well-prepared NPs exhibited a significantly high drug-loading content of 68.15 wt% and held a sustainedrelease property, showing great potential for cancer therapy.…”

Controllable Fabrication and Optical Properties of Uniform Gadolinium Oxysulfate Hollow Spheres

“…Hollow spheres have been attracting great attention due to their superior properties such as high specific surface area, low density, high permeability and therefore show promising potential applications in various fields such as lithium batteries, catalysis and sensing, drug controlled release and delivery, and photonic building blocks, etc123456. Plenty of chemical and physicochemical strategies such as Ostwald ripening7, Kirkendall diffusion8, chemically induced self-transformation9, template-assisted synthesis10, and spray drying followed by annealing1112 have been applied for the design and controlled fabrication of various micro/nanospheres with hollow interiors.…”