2022
DOI: 10.1039/d2py00883a
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Uniform soluble support for the large-scale synthesis of sequence-defined macromolecules

Abstract: Herein, a monodisperse soluble support is explored and used as an effective tool for the large-scale, liquid-phase synthesis of sequence-defined macromolecules. This support, based on a benzyl derivative with three...

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Cited by 12 publications
(11 citation statements)
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“…24 This strategy has recently been adapted by our research group to scale-up the synthesis of oligo(ester urethane)s via a thiolactone chemistry-based iterative protocol, while facilitating the purication and monitoring of the intermediate reaction steps. 25 A variety of chemical backbones that could be synthesized via iterative protocols have been explored in the last years. 26 Among them, sequence-dened oligomers containing amide bonds are gaining major interest in many areas of research.…”
Section: Introductionmentioning
confidence: 99%
“…24 This strategy has recently been adapted by our research group to scale-up the synthesis of oligo(ester urethane)s via a thiolactone chemistry-based iterative protocol, while facilitating the purication and monitoring of the intermediate reaction steps. 25 A variety of chemical backbones that could be synthesized via iterative protocols have been explored in the last years. 26 Among them, sequence-dened oligomers containing amide bonds are gaining major interest in many areas of research.…”
Section: Introductionmentioning
confidence: 99%
“…[8][9][10][11][12] Multiple strategies have been developed in the last decade to achieve the synthesis of sequence dened macromolecules (SDMs). 8,[13][14][15] Thiolactone chemistry, for example, has been explored by our group and others [16][17][18] for the synthesis of a wide range of discrete macromolecules including stereocontrolled oligomers, polyampholytes, 11 and star-shaped macromolecules. 19 This chemistry proved very efficient in advanced applications such as single-chain nanoparticles 12 or data storage [20][21][22] and it has been selected in this research for the design of antibody recruiting polymers.…”
Section: Introductionmentioning
confidence: 99%
“…8,9 There have even been developments in using the benefits of both solution and solid phase synthesis through precipitating anchors. 10 These methodologies generally produce molecules with heteroatom-containing backbones that often made through processes analogous to step-growth polymerisation (Scheme 1a).…”
Section: Introductionmentioning
confidence: 99%