2017
DOI: 10.1371/journal.pone.0172552
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Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups

Abstract: Medulloblastoma comprises four main subgroups (WNT, SHH, Group 3 and Group 4) originally defined by transcriptional profiling. In primary medulloblastoma tissues, these groups are thought to be distinguishable using the immunohistochemical detection of β-catenin, filamin A, GAB1 and YAP1 protein markers. To investigate the utility of these markers for in vitro studies using medulloblastoma cell lines, immunoblotting and indirect immunofluorescence were employed for the detection of β-catenin, filamin A, GAB1 a… Show more

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Cited by 4 publications
(1 citation statement)
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“…Cancer cells exhibit different biochemical patterns and signaling pathways according to the original tissue ( Banti and Hadjikakou, 2016 ; Chlapek et al, 2017 ; Oren et al, 2021 ). If a molecule interacts with a specific protein, for example, it is expected that the biological response reflects the relevance of that protein for cell viability maintenance.…”
Section: Resultsmentioning
confidence: 99%
“…Cancer cells exhibit different biochemical patterns and signaling pathways according to the original tissue ( Banti and Hadjikakou, 2016 ; Chlapek et al, 2017 ; Oren et al, 2021 ). If a molecule interacts with a specific protein, for example, it is expected that the biological response reflects the relevance of that protein for cell viability maintenance.…”
Section: Resultsmentioning
confidence: 99%