Uniformly sized β-cyclodextrin molecularly imprinted microspheres prepared by a novel surface imprinting technique for ursolic acid

Liu, Hanmao; Liu, Chunhai; Yang, Xiaojing; Zeng, Songjun; Xiong, Yan; Xu, Weijian

doi:10.1016/j.aca.2008.08.042

Cited by 78 publications

(41 citation statements)

References 22 publications

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“…The calibration curve that investigated using solutions with MTD concentrations of 0. 5,5,10,15,20,25,50,75,90,95, 100, 105, 115 and 120 µg mL -1 was linear in the range of about 15 to 100 µg mL -1 with coefficient of determination (R 2 ) of 0.991. The limit of the detection of MTD using UV-Vis spectrophotometry was 2.31 µg mL -1 .…”

Section: Analytical Performance and Applicationmentioning

confidence: 96%

“…2,3 Recently, MIPs, as highly selective solid adsorbents, have been widely used in various fields, such as separation and preconcentration, manufacturing of sensors, the stationary phases for chromatography, pseudo immunoassay, catalysis and others. [2][3][4][5][6][7][8][9] In particular, new method of molecularly imprinted solid phase extraction (SPE), in which the MIP-solid adsorbent can selectively extract, has attracted much attention in the separation and enrichment area. 6,[10][11][12] The usual method for preparing MIPs, the entrapping way, has some disadvantages, such as time-consuming and complicated preparation method, less recognition sites within the matrix polymer particles obtained by crushing and grinding imprinted polymeric monolith, and greater diffuse barrier for the template molecules coming from matrix thickness, resulting in poor binding capacity and lower binding kinetics of MIPs to the template molecule.…”

Section: Introductionmentioning

confidence: 99%

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Surface Imprinting of Silica Gel by Methyldopa and Its Application in the Solid Phase Extraction Procedure

Vardini¹,

Mardani²

2017

J. Braz. Chem. Soc.

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An imprinted amino-functionalized silica gel material was prepared by surface molecular imprinting technique combined with a sol-gel process on the supporter of activated silica gel and used as a solid-phase extraction for the extraction and determination of methyldopa (MTD). Non-imprinted silica adsorbent was synthesized without the addition of MTD using the same process. MTD-imprinted and non-imprinted silica adsorbents were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and the static adsorption experiments. The prepared MTD-imprinted silica sorbent demonstrated high adsorption capacity and significant selectivity for MTD in the presence of competitive substances. The maximum adsorption capacity of surface imprinted and non-imprinted silica adsorbent for MTD were 14565.81 and 2990.56 µg g -1 , respectively. The imprinted 3-aminopropyl triethoxysilane (APS) modified silica gel adsorbent provided fast kinetics for the adsorption of MTD. In the operational mode of solid phase extraction (SPE), calibration curve of MTD solution was linear in the range of about 15 to 100 µg mL -1 . The limit of detection (LOD) and precision (RSD) during five replicates were 2.31 µg mL -1 and 5.69%, respectively. At last, the MTD-imprinted material was used as SPE adsorbent to determine the MTD in non-spiked and spiked pharmaceutical samples with satisfactory recovery higher than 94%.

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Section: Analytical Performance and Applicationmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Surface Imprinting of Silica Gel by Methyldopa and Its Application in the Solid Phase Extraction Procedure

Vardini¹,

Mardani²

2017

J. Braz. Chem. Soc.

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“…15 It has been applied to a wide range of target molecules in the field of chromatography, solid phase extraction, controlled drug release, and sensor devices. [16][17][18] However, the traditional MIT has a few limitations, including permanent entrapment of the template and unfavorable kinetics of the adsorption. 19,20 To overcome these drawbacks effectively, the surface MIT was introduced with several advantages such as controllable size, better mechanism, and good reuse performance.…”

Section: Introduction Nmentioning

confidence: 99%

Core–Shell Magnetic Molecularly Imprinted Polymer Prepared for Selectively Removed Indole from Fuel Oil

Niu

Ni²,

Zhou

et al. 2015

Adv Polym Technol

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Magnetic molecularly imprinted polymers (MMIPs) were synthesized for selective recognition and rapid enrichment of indole from a model fuel. The MMIPs were synthesized by precipitation polymerization and a surface molecular imprinting technique, using indole as the template molecule, Fe 3 O 4 nanoparticles as magnetically susceptible components, methylacrylic acid as the functional monomer, and ethylene glycol dimethacrylate as a cross-linker. The properties of the MMIPs were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, and thermogravimetric analysis. The adsorption capacity of indole-molecularly imprinted polymers (MIPs) was 50.25 mg g −1 at 303 K and reached adsorption equilibrium in a short time. Experimental data were modeled with a pseudo-second-order, Langmuir isotherm model. The selective adsorption performance of MIPs was favorable. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 2015, 0, 21596; View this article online at wileyonlinelibrary.com.

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“…The hydroxyl group on b-CDs can act as a polymerization terminal and then form a stable polymer matrix by virtue of a suitable cross-linker. b-CDs have been used as functional monomers or co-monomers to imprint various compounds, such as cholesterol, 77 tryptophan, 78 ursolic acid, 79 bilirubin, 80 dextromethorphan, 81 and cyclobarbital. 82 Generally, the molar ratios between template and monomer in the synthesis process affect the affinity and imprinting efficiency of MIPs.…”

Section: Reagents For Molecular Imprintingmentioning

confidence: 99%

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

2011

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Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).

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Uniformly sized β-cyclodextrin molecularly imprinted microspheres prepared by a novel surface imprinting technique for ursolic acid

Cited by 78 publications

References 22 publications

Surface Imprinting of Silica Gel by Methyldopa and Its Application in the Solid Phase Extraction Procedure

Surface Imprinting of Silica Gel by Methyldopa and Its Application in the Solid Phase Extraction Procedure

Core–Shell Magnetic Molecularly Imprinted Polymer Prepared for Selectively Removed Indole from Fuel Oil

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

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