“…Diffusely increased 18 F-FDG uptake in muscles, as a PET/ CT artifact, has been described in the following situations: insulin administration (6), voluntary physical activity such as chewing gum, exercise or sexual activity (4,5,7), involuntary physical activity such as labored breathing or muscle spasms (8), post surgical changes (9,10), post radiation inflammation (11), dermatomyositis (12), infection (10,13,14), or post injection (15). Unilateral intense muscle 18 F-FDG uptake is rare and has been described in a few cases such as hemiparesis from stroke (16), in patients with multiple sclerosis (17), due to tracer injections (15) or more commonly in certain head and neck muscles (18). Non-compliance with patient instructions during the uptake phase of 18 F-FDG can cause significant artifacts and recent examples in the literature include smartphone use (19), reading a small book and even tapping the foot (20).…”