Unilateral Eales’ disease a case report

Nicolcescu, Andreea; Mocanu, Carmen; Loredana, Dinu; Олару, Андрей; Ionete, Mara; Stefanescu, Dima Alin

doi:10.22336/rjo.2017.27

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…Zhao et al reported that 83% of the patients included in their analysis presented a positive Mantoux test [7]. In our study, we obtained similar results; our patient presented positive Mantoux and QuantiFERON TB Gold tests Immunity-related mechanisms have also been included in various studies, revealing an association between HLA B5, DR1, DR4, autoimmune disease, and Eales disease etiologies [6,12,14].…”

Section: Discussionsupporting

confidence: 86%

“…Immunity-related mechanisms have also been included in various studies, revealing an association between HLA B5, DR1, DR4, autoimmune disease, and Eales disease etiologies [ 6 , 12 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nicolcescu et al reported the case of a 48-year-old woman with unilateral Eales disease. The particularity of this case was that the disease remained unilateral for 9 years after the onset [ 12 ]. Ivanescu et al described the case of a 40-year-old woman diagnosed with bilateral Eales disease whose condition rapidly worsened postpartum, with recurrent vitreous hemorrhages and a limited response to systemic treatment.…”

Section: Discussionmentioning

confidence: 99%

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A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature

Mercuț,

Ică,

Tănasie

et al. 2024

JPM

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Eales disease manifests as an obliterative periphlebitis affecting the retina; it originates from the periphery and progresses posteriorly. It is characterized by retinal vessel wall inflammation, ischemia, and retinal neovascularization. In this report, we present the case of a 34-year-old male who attended our clinic with a sudden blurring of vision in his right eye. A diagnosis of bilateral retinal vasculitis with vitreal hemorrhage was ascertained in his RE. A dilated ocular fundus examination revealed perivenous sheathing of the peripheral vessels in both eyes. Fluorescein angiography indicated dye staining, vessel obliteration, capillary drop-out, areas of non-perfusion and the formation of new vessels. Laboratory tests revealed positive results for Borrelia; a PPD skin test and QuantiFERON TB assay were also positive. The patient underwent bilateral retinal laser pan-photocoagulation, followed by systemic treatment with oral steroids, cephazoline, isoniazid, azathioprine, and entecavir. The steroid dose was progressively reduced over 10 months; the treatment with azathioprine continues, as we are monitoring the patient over the long term. After 3 months, the vasculitis had regressed without any vitreal hemorrhage recurrence. Vision acuity improved from 0.4 to 1 in the patient’s right eye. A multidisciplinary approach, which included collaborative management with gastroenterology, infectious disease, pulmonology, and rheumatology specialists, was essential for the diagnosis, treatment, and long-term follow up of the patient.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature

Mercuț,

Ică,

Tănasie

et al. 2024

JPM

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“…Eales’ disease is an idiopathic peripheral retinal vasculopathy characterized by vasculitis, ischemia, retinal neovascularization, and recurrent vitreous hemorrhages [ 1 ]. Eales’ disease is a diagnosis of exclusion.…”

Section: Introductionmentioning

confidence: 99%

Central retinal artery occlusion as a presenting symptom in Eales’ disease: a case report

et al. 2023

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Background Eales’ disease is an idiopathic peripheral retinal vasculopathy characterized by retinal phlebitis, ischemia, retinal neovascularization, and recurrent vitreous hemorrhages. But CRAO is an unusual presentation. Case presentation A 27-year-old healthy female nurse of Indian descent presented with sudden vision loss in her right eye upon awakening. Central retinal artery occlusion (CRAO), combined with mild central retinal vein occlusion (CRVO), was diagnosed. During the second of three consecutive sessions of hyperbaric oxygen treatments, her vision rapidly improved. One week later, she developed peripheral phlebitis in the same eye. Infectious, inflammatory, and hematologic etiologies were excluded. The systemic evaluation was normal except for a positive Mantoux tuberculin skin test. Following systemic steroidal treatment, she experienced gradual improvement of her vasculitis. Two weeks later, mild retinal phlebitis appeared in her left eye. Eales’ disease was diagnosed after the exclusion of other diseases. Conclusion This is an unusual Eales’ disease case, which presented as combined CRAO with mild CRVO. The association of CRAO and Eales’ disease is reported here for the first time, to our best knowledge.

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“…Moreover, it affects males more than females at 20-40 years of age [3]. Although a unilateral complaint is more frequent, 50%-90% of the patients have bilateral involvement [2,4]. The most prevalent etiological theory is hypersensitivity to tuberculinprotein that develops after exposure to Mycobacterium tuberculosis [5].…”

Section: Introductionmentioning

confidence: 99%

Advanced Eales’ Disease With Neovascular Glaucoma at First Presentation

Alfayyadh¹,

AlAbdulhadi

Almubarak³

2021

Cureus

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Eales' disease is an idiopathic vasculitis that affects the peripheral retina. It is characterized by recurrent vitreous hemorrhage as a complication of retinal neovascularization. It is more prevalent in India and affects young males. Here, we present a patient with neovascular glaucoma as a rare first presentation of Eales' disease. This is a 24-year-old Indian male, who complained of a sudden decrease in vision in the left eye over less than 24 hours, along with frontal headache and eye pain for the last three weeks. Ocular examination revealed peripheral retinal ischemia in the right eye, very high intraocular pressure, rubeosis iridis, vitreous hemorrhage and extensive retinal ischemia in the left eye, vascular sheathing and neovascularization in both eyes. The purified protein derivative skin test was positive. The patient was managed with anti-glaucoma, intravitreal anti-vascular endothelial growth factor and laser photocoagulation. Systemic steroids and anti-tuberculous therapy were also initiated. Neovascular glaucoma is an infrequent complication of Eales' disease. However, the lack of early detection of the disease in the early stages might lead to such serious complications.

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Unilateral Eales’ disease a case report

Cited by 6 publications

References 3 publications

A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature

A Multidisciplinary Approach to the Management of Eales Disease: A Case Report and Review of the Literature

Central retinal artery occlusion as a presenting symptom in Eales’ disease: a case report

Advanced Eales’ Disease With Neovascular Glaucoma at First Presentation

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