Unilateral proptosis as the initial manifestation of malignancy

Abstract

Proptosis, a common sign with a broad differential diagnosis, is defined as anterior displacement and protrusion of one or both orbital globes. Patients can present with varying degrees of chronicity, visual loss and associated symptoms. The etiology of acquired unilateral proptosis is diverse, ranging from benign to life-threatening. The causes of unilateral proptosis include traumatic, vascular, endocrine, inflammatory, infective and malignant. Breast carcinoma is the most common metastatic cause of proptosis; however, proptosis has never been reported as the initial manifestation of breast carcinoma. Our patient presented with unilateral proptosis secondary to an intraorbital lesion and histopathology of orbital lesion was suggestive of metastatic breast adenocarcinoma. She was later diagnosed to have primary breast carcinoma. We present this unusual case of a 56-year-old woman who presented with proptosis as the initial manifestation of a metastatic breast malignancy.

Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis

“…Pyroptosis has been confirmed as an important mechanism for cell growth inhibition. 20 In the current research, cell pyroptosis was Pathway of pyroptosis has been found to be mostly modulated by the interaction with members of the NLRP3 and GSDMD protein family. 21 When the expression of NLRP3 and GSDMD was The apoptosis of BC cells was measured by flow cytometry.…”

Evaluation of Proptosis: A Primer

“…Chronic proptosis occurs in diseases, such as fibrous dysplasia, and tumours, such as dermoid cysts, lymphomas, benign mixed tumours, neurogenic and vascular tumours, and osteomas. 5,21…”

Sinonasal undifferentiated carcinoma – a rare cause of proptosis in elderly

“…P roptosis is described as an abnormal protrusion of the eyeball, reflecting an increase in orbital volume (1) . The causes of unilateral proptosis include trauma, endocrine ophthalmopathy, inflammatory disease like orbital cellulitis, tumour, including orbital haemangioma, malignant lymphomas and metastatic malignant tumours (1,2) . Sinonasal undifferentiated carcinoma (SNUC) is a rare and extremely aggressive malignancy.…”