Unilateral Versus Bilateral Ect in Schizophrenia

Doongaji, D. R.; Jeste, Dilip V.; Saoji, Narendra; Kane, P. V.; Ravindranath, Sneha

doi:10.1192/bjp.123.1.73

Cited by 21 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ottosson (14) has concluded that the antidepressant effect is seizure-related and has a different neural substrate from the associated memory disturbance, and d'Elia (6) and Sand-Stromgren (15) have confirmed that unilateral non-dominant ECT has the same antidepressant effect as bilateral ECT; Doongaji et al . (7) state that both forms of treatment are equally effective in schizophrenia.…”

mentioning

confidence: 99%

Diagnosis and Evaluation of ECT

1976

Canadian Psychiatric Association Journal

View full text Add to dashboard Cite

mentioning

confidence: 99%

Diagnosis and Evaluation of ECT

1976

Canadian Psychiatric Association Journal

View full text Add to dashboard Cite

“…Efficacy The UK ECT Group 51 found that the standardised effect size between the two electrode placements was 0.03 (95% CI -0.91 to 1.03), with a mean change in efficacy score of 0.32 (95% CI -10.56 to 11.99), indicating no difference between the two electrode placements. The Cochrane Schizophrenia Group ECT review 50 found neither unilateral nor bilateral ECT to be superior in terms of global improvement (two RCTs, 184,191 RR = 0.79, not improved at end of course of ECT, 95% CI 0.5 to 1.4, n = 78). They report that none of the three trials reported long-term efficacy data.…”

Section: Unilateral Versus Bilateral Ectmentioning

confidence: 99%

“…The UK ECT Group 51 included two trials 191,192 containing 147 patients. Adolescents were included in one trial 191 and unmodified ECT was used in the other. 192 Neuroleptic medication was not coadministered in either of these studies.…”

Section: Unilateral Versus Bilateral Ectmentioning

confidence: 99%

Clinical and cost-effectiveness of electroconvulsive therapy for depressive illness, schizophrenia, catatonia and mania: systematic reviews and economic modelling studies

Greenhalgh

Knight²,

Hind³

et al. 2005

Health Technol Assess

173

View full text Add to dashboard Cite

Real ECT is probably more effective than sham ECT, but as stimulus parameters have an important influence on efficacy, low-dose unilateral ECT is no more effective than sham ECT. ECT is probably more effective than pharmacotherapy in the short term and limited evidence suggests that ECT is more effective than repetitive transcranial magnetic stimulation. Tricyclic antidepressants (TCAs) may improve the antidepressant effect of ECT during the course of treatment. Continuation pharmacotherapy with TCAs combined with lithium in people who have responded to ECT reduces the rate of relapses. Overall, gains in the efficacy of the intervention depending on the stimulus parameters of ECT are achieved only at the expense of an increased risk of cognitive side-effects. Limited evidence suggests these effects do not last beyond 6 months, but there is no evidence examining the longer term cognitive effects of ECT. There is little evidence of the long-term efficacy of ECT. ECT either combined with antipsychotic medication or as a monotherapy is not more effective than antipsychotic medication in people with schizophrenia. More research is needed to examine the long-term efficacy of ECT and the effectiveness of post-ECT pharmacotherapy, the short-term and longer term cognitive side-effects of ECT, and the impact of ECT on suicide and all-cause mortality. Further work is needed to examine the information needs of people deciding whether to accept ECT and how their decision-making can be facilitated. More research is also needed on the mechanism of action of ECT. Finally, the quality of reporting of trials in this area would be vastly improved by strict adherence to the Consolidated Standards of Reporting Trials recommendations. Economic analysis may identify areas in which research would be best targeted by identifying parameters where reducing the level of uncertainty would have the most effect in helping to make the decision on whether ECT is a cost-effective treatment.

show abstract

“…Doongaji et al (1973) randomized 54 right‐handed patients with schizophrenia to a minimum of six BL, RUL, or LUL ECT. It must be noted that, unlike in the rest of the literature reviewed here, ECT was administered completely ‘unmodified’, that is, with no anesthesia or preanesthetic medication.…”

Section: Literature Reviewmentioning

confidence: 99%

A systematic review of left unilateral electroconvulsive therapy

Kellner

Farber

Chen

et al. 2017

Acta Psychiatr Scand

View full text Add to dashboard Cite

Overall, the efficacy of LUL electrode placement for the treatment of depression and psychosis is similar to that of right unilateral (RUL) and bilateral (BL) electrode placements. Patients receiving LUL ECT tend to experience more verbal memory impairment than patients receiving RUL ECT, but less verbal impairment than patients receiving BL ECT. In contrast, patients receiving LUL ECT tended to experience the least visual and nonverbal memory impairment, compared to patients receiving RUL or BL ECT.

show abstract

Unilateral Versus Bilateral Ect in Schizophrenia

Cited by 21 publications

References 17 publications

Diagnosis and Evaluation of ECT

Diagnosis and Evaluation of ECT

Clinical and cost-effectiveness of electroconvulsive therapy for depressive illness, schizophrenia, catatonia and mania: systematic reviews and economic modelling studies

A systematic review of left unilateral electroconvulsive therapy

Contact Info

Product

Resources

About