Unique bioactive polyphenolic profile of guava (<i>Psidium guajava</i>) budding leaf tea is related to plant biochemistry of budding leaves in early dawn

Chang, Chi Huang; Hsieh, Chiu Lan; Wang, Hui Er; Peng, Chiung Chi; Chyau, Charng-Cherng; Peng, Robert Y.

doi:10.1002/jsfa.5832

Cited by 33 publications

(26 citation statements)

References 20 publications

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“…Content of total flavonoids (TFC) was determined by the spectrophotometric method [13] using rutin as the standard. Briefly, 0.25 mL sample was added to 75 μ L NaNO 2 (50 mg/mL) in a 5 mL cuvette.…”

Section: Methodsmentioning

confidence: 99%

Comparative Studies on Bioactive Constituents in Hawk Tea Infusions with Different Maturity Degree and Their Antioxidant Activities

Yuan

Jia

Ding

et al. 2014

The Scientific World Journal

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Hawk tea (Litsea coreana var. lanuginose) is a very popular herbal tea in the southwest of China. According to the maturity degree of raw materials, Hawk tea can usually be divided into three types: Hawk bud tea (HB), Hawk primary leaf tea (HP), and Hawk mature leaf tea (HM). In this study, some of the bioactive constituents and antioxidant properties of the three kinds of Hawk tea infusions were comparatively investigated. The results showed that the contents of total flavonoids, vitamin C, and carbohydrates in Hawk bud tea infusion (HBI) were higher than those in Hawk primary leaf tea infusion (HPI) and Hawk mature leaf tea infusion (HMI). HPI had higher contents of total polyphenols and exhibited better DPPH radical scavenging activity and ferric reducing activity power. HBI could provide more effective protection against erythrocyte hemolysis. As age is going from bud to mature leaf, the ability to inhibit the formation of low density lipoprotein (LDL) conjugated diene and the loss of tryptophan fluorescence decreased. The bioactive constituents and antioxidant activities of Hawk tea infusions were significantly affected by the maturity degree of the raw material.

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Section: Methodsmentioning

confidence: 99%

Comparative Studies on Bioactive Constituents in Hawk Tea Infusions with Different Maturity Degree and Their Antioxidant Activities

Yuan

Jia

Ding

et al. 2014

The Scientific World Journal

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“…Two flavonol compounds (compounds 22 and 23) with molecular ion at m/z 479 and fragments at m/z 317 and 316 were identified as myricetin-hexoside isomers [11]. Two compounds (25 and 26) corresponding to [M-H] − signals at m/z 615 were also detected.…”

Section: Identification Of Polar Compoundsmentioning

confidence: 99%

“…Phenolic and other polar compounds in the extracts obtained from guava leaves were identified using a method introduced by Chang et al [11], with slight modifications. Briefly, HPLC analyses were performed using a HP 1100 Series instrument (Hewlett Packard, Wilmington, DE, USA) equipped with a binary pump delivery system, a degasser (model G1322A), an autosampler (Automatic Liquid Sampler, ALS, model G1312A), a HP diode-array UV-VIS detector (DAD, model G1315A), and a quadrupole HP-Mass Spectrometer Detector (MSD, model G1946A); integration and data elaboration were performed using Chemstation software (Hewlett Packard).…”

Section: Hplc-esi-ms Analysismentioning

confidence: 99%

“…A Phenomenex Luna C18 analytical column (150 mm × 2.0 mm, particle size 3 m) (Phenomenex Inc., Torrance, CA, USA) was used for polar compounds separation. All analyses were carried out at room temperature using the gradient proposed by Chang et al [11]. MS analysis was carried out using an electrospray ionization (ESI) interface in negative ionization mode at the following conditions: drying gas flow (N 2 ), 9.0 L/min; nebulizer pressure, 50 psi; gas drying temperature, 350 ∘ C; capillary voltage, 3500 V; and fragmentor voltage and scan range, 100 V and m/z 50-1000, respectively.…”

Section: Hplc-esi-ms Analysismentioning

confidence: 99%

“…Four compounds (compounds 20, 24, 27, and 29) reported a molecular ion at m/z 449 and two major fragments at m/z 316 and 317. According to Chang et al [11], these compounds were identified as myricetin-arabinoside/xylopyranoside isomers.…”

Section: Identification Of Polar Compoundsmentioning

confidence: 99%

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Determination of Polar Compounds in Guava Leaves Infusions and Ultrasound Aqueous Extract by HPLC-ESI-MS

Díaz‐de‐Cerio

Verardo

Gómez-Caravaca

et al. 2015

Journal of Chemistry

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Literature lacks publications about polar compounds content in infusion or guava leaves tea. Because of that, a comparison between different times of infusion and a conventional ultrasound aqueous extract was carried out. Several polar compounds have been identified by HPLC-ESI-MS and their antioxidant activity was evaluated by FRAP and ABTS assays. Four different classes of phenolic compounds (gallic and ellagic acid derivatives, flavonols, flavanones, and flavan-3-ols) and some benzophenones were determined. The quantification results reported that the order, in terms of concentration of the classes of polar compounds in all samples, was flavonols > flavan-3-ols > gallic and ellagic acid derivatives > benzophenones > flavanones. As expected, the aqueous extract obtained by sonication showed the highest content in the compounds studied. Significative differences were noticed about the different times of infusion and five minutes was the optimal time to obtain the highest content in polar compounds using this culinary method. All the identified compounds, except HHDP isomers and naringenin, were positively correlated with antioxidant activity.

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Effect of phenolic compounds from the leaves of Psidium guajava on the activity of three metabolism‐related enzymes

Ahmed

Aldesouki

Badria

2020

Biotech and App Biochem

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Enzyme activity modulation by synthetic compounds provide strategies combining the inhibitory and therapeutic mode of action of the confirmed inhibitors. However, natural modulators could offer a valuable alternative for synthetic ones for the treatment of different chronic diseases (diabetes, hypertension, cancer); due to the numerous side effects of the latter. In vitro screening assays were conducted for Psidium guajava leaf methanolic extract against three metabolism-related enzymes; α-amylase, tyrosinase, and hyaluronidase. The obtained results showed that the examined extract retained weak and moderate multitarget inhibition against α-amylase, tyrosinase, and hyaluronidase, respectively; however, the leaf fractions exhibited stronger inhibitions for the three investigated enzymes. Fractionation of P. guajava leaf extract revealed that anthraquinones and ellagic acid are of the major active compounds with inhibitory activities for α-amylase, tyrosinase, and hyaluronidase. Kinetic studies showed that quinalizarin inhibition is competitive for both α-amylase and hyaluronidase, and ellagic acid inhibition for tyrosinase and hyaluronidase is competitive and un-competitive, respectively. The molecular docking studies of quinalizarin and ellagic acid with α-amylase, tyrosinase, and hyaluronidase showed high binding energies with different bonds stabilizing the ligand-protein complex. Compiling all obtained results led to conclude that both P. guajava leaf fractions, quinalizarin and ellagic acid, have multitarget activities with potential therapeutic applications in many metabolic disorders.

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Unique bioactive polyphenolic profile of guava (Psidium guajava) budding leaf tea is related to plant biochemistry of budding leaves in early dawn

Cited by 33 publications

References 20 publications

Comparative Studies on Bioactive Constituents in Hawk Tea Infusions with Different Maturity Degree and Their Antioxidant Activities

Comparative Studies on Bioactive Constituents in Hawk Tea Infusions with Different Maturity Degree and Their Antioxidant Activities

Determination of Polar Compounds in Guava Leaves Infusions and Ultrasound Aqueous Extract by HPLC-ESI-MS

Effect of phenolic compounds from the leaves of Psidium guajava on the activity of three metabolism‐related enzymes

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