Unique cascade ring-opening/cyclization reaction of azlactones and DBU or DBN: Synthesis of new pyrrolam A analogues

CsF-Catalyzed Transannulation Reaction of Oxazolones: Diastereoselective Synthesis of Diversified trans-N-(6-Oxo-1,4,5,6-tetrahydropyrimidin-5-yl)benzamides with Arylidene Azlactones and Amidines

“…Arising from the capability of azlactones to act as 1,3-dipole precursors, (e.g., domino cyclization reactions), the attractiveness of 4-arylidene-2-aryl-5­(4 H )-oxazolones (arylidene azlactones) makes them profitable intermediates and building blocks for preparation of miscellaneous compounds (e.g., non-natural amino acids and heterocycles , ). Using this property, we have recently reported the ring-opening/cyclization reaction of azlactones with DBU and DBN to generate pyrrolam A analogs with a high antimicrobial activity.…”

Multicomponent Synthesis of Diversified Chromeno[3,2-d]oxazoles

“…The chromeno-oxazole motif should be accessible by efficient one-pot sequential multistep processes; as part of our interest in the development of sustainable chemistry, we desired a metal-free route, which is comparatively rare . We report here a metal-catalyst-free domino single vessel procedure to furnish novel chromeno­[3,2- d ]­oxazole derivatives in propylene carbonate (PC) as the solvent.…”