2014
DOI: 10.1016/j.mrfmmm.2014.03.008
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Unique molecular alteration patterns in von Hippel-Lindau (VHL) gene in a cohort of sporadic renal cell carcinoma patients from Pakistan

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Cited by 7 publications
(8 citation statements)
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“…The condition of VHL promoter methylation has been reported in various cancers, including papillary thyroid carcinoma [35], RCC [36], and colorectal cancer [37]. However, we found that the reported frequency of VHL promoter methylation in RCC is still controversial, with a range from 0% [38] to 35.3% [20]. Therefore, the present meta-analysis was performed to further validate the relationship between VHL promoter hypermethylation and RCC.…”
Section: Discussionmentioning
confidence: 82%
See 1 more Smart Citation
“…The condition of VHL promoter methylation has been reported in various cancers, including papillary thyroid carcinoma [35], RCC [36], and colorectal cancer [37]. However, we found that the reported frequency of VHL promoter methylation in RCC is still controversial, with a range from 0% [38] to 35.3% [20]. Therefore, the present meta-analysis was performed to further validate the relationship between VHL promoter hypermethylation and RCC.…”
Section: Discussionmentioning
confidence: 82%
“…Eventually, thirteen eligible studies with 1,998 RCC patients and 294 controls were included in our study (Fig. 1) [20][21][22][23][24][25][26][27][28][29][30][31][32]. Seven of these studies, including 596 RCC patients and 294 nonmalignant samples, evaluated the association of VHL promoter hypermethylation with RCC risk.…”
Section: Basic Characteristics Of the Included Studiesmentioning
confidence: 99%
“…Inactivation of the VHL gene due to mutation or hypermethylation is the most frequently described genetic alteration in ccRCC. According to some reports the prevalence may reach as much as 60–80% [ 45 47 ]. Induction of IGFBP-3 through HIF-1α-mediated mRNA transcription has been described by Natsuizaka et al .…”
Section: Discussionmentioning
confidence: 99%
“…Since Neumann et al reported that RCCs developing in patients with VHL disease had a better prognosis than sporadic RCCs [ 18 ], a series of studies investigated the correlation of somatic VHL alteration with pathological characteristics or prognosis in ccRCCs [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. Some studies found that VHL alteration correlated with favorable pathological features or prognosis [ 22 , 28 , 29 , 30 ].…”
Section: Introductionmentioning
confidence: 99%
“…Salinas-Sánchez et al reported that VHL methylation was associated with worse survival [ 31 ]. Other studies failed to demonstrate the pathological or prognostic significance of VHL alteration in patients with ccRCC [ 19 , 20 , 21 , 23 , 24 , 25 , 26 , 27 ].…”
Section: Introductionmentioning
confidence: 99%