Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications

Kong, Fen‐Ying; Zhang, Jinwei; Li, Rongfang; Wang, Zhong‐Xia; Wang, Wen‐Juan; Wang, Wei

doi:10.3390/molecules22091445

Cited by 471 publications

(217 citation statements)

References 65 publications

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“…The inorganic nanomaterial mainly used to deliver miRNA drugs is based on gold NPs due to their stability, surface modification ability, and high biocompatibility [104][105][106]. MiRNAs bound to gold nanoparticles have been mainly developed by using cysteamine-functionalized gold nanoparticles (AuNPs).…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Grieco

Brusco

Licata

et al. 2019

IJMS

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Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused by oxidative stress. The molecular mechanisms involved inβ cell dysfunction and in response to oxidative stress are also regulated by microRNAs (miRNAs). miRNAs are a class of negative gene regulators, which modulate pathologic mechanisms occurring in diabetes and its complications. Although several pharmacological therapies specifically targeting miRNAs have already been developed and brought to the clinic, most previous miRNA-based drug delivery methods were unable to target a specific miRNA in a single cell type or tissue, leading to important off-target effects. In order to overcome these issues, aptamers and nanoparticles have been described as non-cytotoxic vehicles for miRNA-based drug delivery. These approaches could represent an innovative way to specifically target and modulate miRNAs involved in oxidative stress in diabetes and its complications. Therefore, the aims of this review are: (i) to report the role of miRNAs involved in oxidative stress in diabetes as promising therapeutic targets; (ii) to shed light onto the new delivery strategies developed to modulate the expression of miRNAs in diseases.

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Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Grieco

Brusco

Licata

et al. 2019

IJMS

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“…This strategy offers the advantage to allow for the controlled release of the therapeutic active compound at a specific location and in a controlled manner. The therapeutic dosage needed is therefore reduced and the side effects diminished, positively impacting on the treatment outcomes and safety [75]. An extensive literature review has been recently published on this topic [76].…”

Section: Ionizing Radiations As External Physical Stimulimentioning

confidence: 99%

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Movia

Benhaddada

Spadavecchia

et al. 2020

Precision Nanomedicine

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Graphical abstract KeywordsGold nanoparticle 1 ; external stimuli; physical stimuli; physically triggered nanomedicine. Quote this article as: Movia D, Benhaddada M, Jolanda Spadavecchia J, Prina-Mello A, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies, Precis. Nanomed. 2020 April;3(2):495-524, https://doi. AbstractNanomedicine aims at enhancing treatment efficiency and/or improving diagnostic sensitivity by better controlling several critical parameters, such as tissue targeting and off-target toxicity. More recently, advanced nanomedicine products have been developed to achieve spatially and temporally controlled therapy and diagnosis. This review focuses on gold nanomaterials (AuNMs) and alloy/hybrid AuNMs that can be used in stimuli-responsive strategies for therapeutic and diagnostic applications. Endogenous and/or exogenous stimuli can be used as a trigger for such systems. Herein, we focus on those activated by exogenous stimuli. Our review starts from one specific externally activated product, Aurolase®, which recently underwent clinical studies. Further we continue describing a specific physically triggered category, for which the exogeneous stimulus applied induces a structural transformation or modification that is essential for their therapeutic and/or diagnostic action. Gold nanomaterials are grouped both by the nature of the function they exert (therapeutic or diagnostic) and the stimuli class.

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“…AuNPs are interesting candidates for their biomedical applications in cancer (radiotherapy 26 and photothermal therapy 27 ), imaging and drug delivery 28 . Their surface functionalization with therapeutics or peptides is well-documented.…”

Section: Introductionmentioning

confidence: 99%

Coiled Coil Affinity-Based Systems for the Controlled Release of Biofunctionalized Gold Nanoparticles from Alginate Hydrogels

et al. 2019

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Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled-coil affinity pair to mediate the release of gold nanoparticles from alginate scaffolds. On the one hand, the gold nanoparticles were functionalized with Ecoil-tagged epidermal growth factor (EGF). The bioactivity of the grafted EGF and the bioavailability of the Ecoil moiety were confirmed by EGF receptor phosphorylation assays and by capturing the functionalized nanoparticles on a Kcoilderivatized surface, respectively. On the other hand, alginate chains were modified with azidohomoalanine Kcoil (Aha-Kcoil) by azide-alkyne click chemistry. The hybrid system was formed by dispersing NPs functionalized with Ecoil-tagged EGF in alginate hydrogels containing either 0, 10 or 20% of Kcoil-modified alginate (Alg-Kcoil). With 20% of Alg-Kcoil, the release of Ecoilfunctionalized NPs was reduced by half when compared to the release of NPs without Ecoil, whereas little to no differences were noticed with either 0 or 10% of Alg-Kcoil. Differential dynamic microscopy was used to determine the diffusion coefficient of the NPs, and the results showed a decrease in the diffusion coefficient of Ecoil-functionalized NPs, when compared to bare pegylated NPs. Altogether, our data demonstrated that the E/K coiled-coil system can control the release of NPs in a high Kcoil content alginate gel, opening diverse applications in drug delivery.

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Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications

Cited by 471 publications

References 65 publications

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Coiled Coil Affinity-Based Systems for the Controlled Release of Biofunctionalized Gold Nanoparticles from Alginate Hydrogels

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