2015
DOI: 10.1080/15384101.2015.1093420
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Unlocking ATP13A2/PARK9 activity

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Cited by 11 publications
(13 citation statements)
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“…Here, we tested whether the activation of ATP13A2 during metal toxicity also depends on PA and/or PI(3,5)P2. In the stable SHSY5Y cell lines we observed that similar to rotenone and MPP+ toxicity ATP13A2 overexpression protected against, whereas KD sensitized cells to metal toxicity following exposure to Zn 2+ , Mn 2+ , and Fe 3+ (Figures 4(a) and 4(b) ), in line with previous reports [ 14 , 16 , 17 , 19 , 23 ].…”
Section: Resultssupporting
confidence: 92%
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“…Here, we tested whether the activation of ATP13A2 during metal toxicity also depends on PA and/or PI(3,5)P2. In the stable SHSY5Y cell lines we observed that similar to rotenone and MPP+ toxicity ATP13A2 overexpression protected against, whereas KD sensitized cells to metal toxicity following exposure to Zn 2+ , Mn 2+ , and Fe 3+ (Figures 4(a) and 4(b) ), in line with previous reports [ 14 , 16 , 17 , 19 , 23 ].…”
Section: Resultssupporting
confidence: 92%
“…The catalytic activity of ATP13A2 provides cellular protection against various PD-related insults like mitochondrial stress [ 14 , 23 ] and metal exposure (Mn 2+ [ 16 , 17 ], Zn 2+ [ 18 ], and Fe 3+ [ 19 ]). Here we established that these various cytoprotective effects depend on the same activation mechanism of ATP13A2 involving an N-terminal lipid switch.…”
Section: Discussionmentioning
confidence: 99%
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