Unlocking the secrets: Volatile Organic Compounds (VOCs) and their devastating effects on lung cancer

Hussain, Md Sadique; Gupta, Gaurav; Mishra, Riya; Patel, Neeraj; Gupta, Saurabh; Alzarea, Sami I.; Kazmi, Imran; Kumbhar, Popat; Disouza, John; Dureja, Harish; Kukreti, Neelima; Singh, Sachin Kumar; Dua, Kamal

doi:10.1016/j.prp.2024.155157

Cited by 22 publications

(2 citation statements)

References 309 publications

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“…These compounds are hydrocarbons, the concentration of which is determined only for the sum of the entire group, and there are no tests of their qualitative composition. Among particularly harmful hydrocarbons, two groups of compounds deserve attention: polycyclic aromatic hydrocarbons (PAHs) 34 and volatile organic compounds (VOCs) 35 , because many substances belonging to these groups have proven highly toxic, carcinogenic, mutagenic or genotoxic effects. Nitrogen oxides (mainly nitrogen oxide NO and nitrogen dioxide NO 2 ) 36 and carbon monoxide CO 37 are single compounds directly covered by emission limits and well recognized in terms of toxicology.…”

Section: Discussionmentioning

confidence: 99%

Low-vacuum SEM imaging and viability test of L929 cells exposed to a Euro 6 diesel exhaust gas mixture in a BAT-CELL chamber in comparison with hydrocarbons emission

Kęska,

Rusak,

Włostowski

et al. 2024

Sci Rep

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Exhaust emissions, which count among the most common causes of premature death worldwide, can cause irreversible changes in cells, leading to their damage or degeneration. In this research, L929 line cells were observed after exposure in the BAT-CELL chamber to exhaust gases emitted from a Euro 6 compression-ignition engine. Real road traffic conditions were simulated, taking into account air resistance while driving at speeds of 50 km/h, 120 km/h and idling engine. Morphological analysis of the cells was performed using an environmental scanning electron microscope. It has been observed that diesel exhaust fumes can cause inflammation, which can induce apoptosis or leads to necrotic cell death. The impact of the vehicle exhaust gases can inhibit cell proliferation by almost three times. Moreover, a correlation has been observed between the speed of the inflammatory reaction in cells and the presence of specific hydrocarbon compounds that determine the toxicity of exhaust gases. Research has shown that the toxicity of the emitted exhaust gases has been the highest at the driving speed of 120 km/h. In order to reduce the harmful effects of exhaust emissions, ecological alternatives and the supplementation of legal provisions regarding the compounds subject to limitation are necessary.

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Section: Discussionmentioning

confidence: 99%

Low-vacuum SEM imaging and viability test of L929 cells exposed to a Euro 6 diesel exhaust gas mixture in a BAT-CELL chamber in comparison with hydrocarbons emission

Kęska,

Rusak,

Włostowski

et al. 2024

Sci Rep

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“…Benzene has been classified as a group 1A carcinogen [30] as its toxic effects on the hematopoietic system are well known [31]. Other well-researched VOCs include polycyclic aromatic hydrocarbons, formaldehyde, and benzo[a]pyrene, with their cancer-causing potential confirmed by comprehensive data [32][33][34]. One study [35] emphasized that exposure to vinyl chloride can provoke a relatively rare cancer, liver angiosarcoma [35].…”

Section: Introductionmentioning

confidence: 99%

Assessing Benzene and TVOC Pollution and the Carcinogenic and Noncarcinogenic Risks to Workers in an Industrial Plant in Southeastern Romania

Barbeş,

Bărbulescu,

Barbeș

2024

Toxics

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The article aims to analyze the pollution with Volatile Organic Compounds (VOC) emitted from the biggest refinery in Romania, using the daily and monthly series registered for two years in two sites on the industrial platform, and the carcinogenic and noncarcinogenic risks for workers at the industrial plant. Since the values of the basic statistics (minimum, maximum, and average) and outliers indicate that most recorded values exceed the maximum admissible limits established by law, the Peaks Over Threshold (POT) method was utilized to model the maximum values of the series and determine the return levels for benzene and total VOC (TVOC). Given the high values obtained for relatively short return periods, indicating potential danger for the workers, we assessed the noncarcinogenic and carcinogenic risks to benzene and TVOC exposure by computing the hazard index (HI) and lifetime cancer risk (LCR). The results indicate that 43.75% of the HI values are above 1, indicating a relatively high noncarcinogenic risk for different categories of workers. LRC indicates a high LRC for 93.75% of the workers in all considered categories exposed to TVOC.

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MgO-Modified Activated Carbon Fibers for Enhanced Adsorption of Toluene: Efficiency and Mechanism

Wu,

He,

Chu

et al. 2024

Korean J. Chem. Eng.

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Unlocking the secrets: Volatile Organic Compounds (VOCs) and their devastating effects on lung cancer

Cited by 22 publications

References 309 publications

Low-vacuum SEM imaging and viability test of L929 cells exposed to a Euro 6 diesel exhaust gas mixture in a BAT-CELL chamber in comparison with hydrocarbons emission

Low-vacuum SEM imaging and viability test of L929 cells exposed to a Euro 6 diesel exhaust gas mixture in a BAT-CELL chamber in comparison with hydrocarbons emission

Assessing Benzene and TVOC Pollution and the Carcinogenic and Noncarcinogenic Risks to Workers in an Industrial Plant in Southeastern Romania

MgO-Modified Activated Carbon Fibers for Enhanced Adsorption of Toluene: Efficiency and Mechanism

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