2024
DOI: 10.1093/nar/gkae660
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Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea

Min-Guan Lin,
Cheng-Yi Yen,
Yo-You Shen
et al.

Abstract: Genome segregation is a fundamental process that preserves the genetic integrity of all organisms, but the mechanisms driving genome segregation in archaea remain enigmatic. This study delved into the unknown function of SegC (SSO0033), a novel protein thought to be involved in chromosome segregation in archaea. Using fluorescence polarization DNA binding assays, we discovered the ability of SegC to bind DNA without any sequence preference. Furthermore, we determined the crystal structure of SegC at 2.8 Å reso… Show more

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