Unreliable rectal absorption of Cisapride in horses

Steel, C. M.; Bolton, John R.; Preechagoon, Yupaporn; Charles, Bruce G.

doi:10.1111/j.2042-3306.1999.tb03795.x

Cited by 16 publications

(9 citation statements)

References 12 publications

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“…The low bioavailability may have resulted from anatomical differences of the equine colon, inactivation or binding of the drug by fecal material, poor drug retention, or the physicochemical properties of the drug as suggested by Steel et al (1999) in a study on rectal absorption of cisapride in horses. Although the rectal bioavailability in our study was low, it was higher and more consistent than that of cisapride (Steel et al, 1999). In one horse metronidazole p.r.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of metronidazole in horses after intravenous, rectal and oral administration

Steinman

Gips

Lavy

et al. 2000

Vet Pharm & Therapeutics

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Metronidazole pharmacokinetics in horses was studied after intravenous (i.v.), rectal (p.r.) and oral (p.o.) administration at 20 mg/kg using a triple crossover study design. Metronidazole mean+/-SD half-life was 196+/-39, 212+/-30 and 240+/-65 min after i.v., p.r. and p.o. administration, respectively. The metronidazole clearance was 2.8 (mL/min/kg) and the volume of distribution at steady state was 0.68 L/kg. The pharmacokinetic parameters calculated for metronidazole after administration of the drug by the various routes showed that bioavailability (74+/-18 vs. 30+/-9%) and maximum serum concentration (22+/-8 vs. 9+/-2 microg /mL) were significantly higher after p.o. administration compared with p.r. administration. There were no significant differences in mean absorption time (45+/-69 vs. 66+/-18 min) and the time to reach maximum serum concentration (65+/-36 vs. 58+/-18 min). The results indicated that p.r. administration of metronidazole to horses, although inferior to p.o. administration in terms of bioavailability, provides an alternative route of administration when p.o. administration cannot be used.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of metronidazole in horses after intravenous, rectal and oral administration

Steinman

Gips

Lavy

et al. 2000

Vet Pharm & Therapeutics

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“…Pretreatment with cisapride can block the delay in gastric emptying induced by lipopolysaccharide in horses (Valk et al 1998a). Cisapride is currently available only for oral administration, which is a drawback for use in horses with DPJ, and rectal absorption of cisapride is poor (Cook et al 1997;Steel CM et al 1999).…”

Section: Treatmentmentioning

confidence: 99%

Duodenitis-Proximal Jejunitis

Freeman¹

2003

Current Therapy in Equine Medicine

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“…However, in addition to their actions at 5-HT4 receptors triggering prokinetic effects, they also act at other receptors or ion channels such as dopamine receptors or potassium channels with major impact on their tolerability and safety profile Mitcheson et al 2000). Moreover, cisapride as an oral formulation may not be very useful clinically, especially in horses with continual gastric reflux (Cook et al 1997;Steel et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Tegaserod (HTF 919) stimulates gut motility in normal horses

Lippold

Hildebrand²,

Straub

2004

Equine Veterinary Journal

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Summary Reasons for performing study: It has been shown that the selective 5‐HT4 receptor agonist tegaserod induces an increase in frequency and amplitude of contractions in isolated muscle preparations of equine ileum and pelvic flexure. Objectives: To investigate the effects of tegaserod on gut motility and transit of spheres in normal horses. Methods: Six mature Freiberger horses were kept under standardised conditions. Effects of tegaserod (0.02 mg/kg bwt i.v. b.i.d. for 2 days) or vehicle on intestinal transit of barium‐filled spheres, defaecation and gut sounds were studied in a cross‐over design. Spheres were given via stomach tube prior to the first dosing of tegaserod or vehicle. Faeces were collected every 3 h and spheres eliminated were identified radiologically in the faeces. Results: Tegaserod significantly accelerated the gastrointestinal (GI) transit time of spheres and increased the frequency of defaecation and scores of gut sounds compared to vehicle. The compound was well tolerated; no effects on behaviour, body temperature, heart rate, respiratory rate and clinical laboratory data were observed. Conclusions: Tegaserod efficaciously stimulated motility and accelerate GI transit in healthy horses. Potential relevance: Tegaserod may offer therapeutic potential in horses suffering from impaction or paralytic ileus.

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Unreliable rectal absorption of Cisapride in horses

Cited by 16 publications

References 12 publications

Pharmacokinetics of metronidazole in horses after intravenous, rectal and oral administration

Pharmacokinetics of metronidazole in horses after intravenous, rectal and oral administration

Duodenitis-Proximal Jejunitis

Tegaserod (HTF 919) stimulates gut motility in normal horses

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