2024
DOI: 10.1021/acs.analchem.4c04462
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Untargeted Spatial Metabolomics and Spatial Proteomics on the Same Tissue Section

Gregory W. Vandergrift,
Marija Veličković,
Le Z. Day
et al.

Abstract: An increasing number of spatial multiomic workflows have recently been developed. Some of these approaches have leveraged initial mass spectrometry imaging (MSI)-based spatial metabolomics to inform the region of interest (ROI) selection for downstream spatial proteomics. However, these workflows have been limited by varied substrate requirements between modalities or have required analyzing serial sections (i.e., one section per modality). To mitigate these issues, we present a new multiomic workflow that use… Show more

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