Unusual and aggressive thrombotic onset in two children with antiphospholipid-antibody syndrome and systemic lupus erythematosus

Roldan-Molina, Rosa; Román, José; Escudero, Alejandro; Pérez-Guijo, Verónica; Castro, Carmen; Martínez, Francisco García; Collantes, Eduardo

doi:10.1016/s1297-319x(03)00133-7

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…However, it has direct neurological implications and, as in our study, isolated cases have been reported in JSLE associated with the presence of anti-phospholipid antibody 41,42 .…”

Section: Discussionsupporting

confidence: 57%

Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system

Spinosa

Bandeira

Liberalesso

et al. 2007

Arq. Neuro-Psiquiatr.

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OBJECTIVE: To characterize neurological involvement in juvenile systemic lupus erythe-matosus. METHOD: The charts of all patients with the diagnosis of systemic lupus erythematosus before the age of 16 years, followed at the Rheumatology Unit of Pequeno Príncipe Hospital, from January 1992 to January 2006, were retrospectively reviewed, highlighting neuropsychiatric aspects. RESULTS: Forty-seven patients were included. Neuropsychiatric syndromes were found 29 (61.7%): seizures (17 / 36.2%), intractable headache (7 / 14.9%), mood disorders (5 / 10.6%), cerebrovascular disease (4 / 8.5%), acute confusional state (3 / 6.4%), aseptic meningitis (3 / 6.4%), psychosis (3 / 6.4%), chorea (3 / 6.4%), Guillain-Barré syndrome (2 / 4.3%) and cranial neuropathy (1 / 2.1%). Morbidity indexes (SLEDAI and SLICC) were higher among patients with neuropsychiatric manifestations (p<0.05). CONCLUSION: Neuropsychiatric syndromes are frequent, and add significant morbidity to juvenile systemic lupus erythematosus.

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“…However, it has direct neurological implications and, as in our study, isolated cases have been reported in JSLE associated with the presence of anti-phospholipid antibody 41,42 .…”

Section: Discussionsupporting

confidence: 57%

Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system

Spinosa

Bandeira

Liberalesso

et al. 2007

Arq. Neuro-Psiquiatr.

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“…Membranous nephropathy has only rarely been reported in children with lupus nephropathy. A total of 46 children and adolescents with lupus membranous nephropathy have been reported in the English literature, including two series of eleven [1] and ten [2], three series of five [3][4][5], and several sporadic cases [6][7][8][9][10][11]. However, compared to adult series, our pediatric series shows a higher frequency (18% vs 12%) of membranous nephropathy among patients with a lupus nephropathy [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Prognosis of lupus membranous nephropathy in children

et al. 2006

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The occurrence of membranous nephropathy in pediatric series of systemic lupus erythematosus has been reported only rarely, probably due to a very low frequency. One hundred fifty-four children who were seen in 100 French pediatric centers between January 2002 and April 2005 were included. Fifteen (12 girls and three boys) out of the 81 (18.5 %) children with renal involvement presented histological features of membranous nephropathy. Their ages ranged from six to 15 years old (mean=11.3) at the age of SLE diagnosis and 8/15 children were of African origin. Isolated membranous nephropathy was observed in nine patients, of whom five patients displayed a complete recovery following immunosuppressive treatment. Associated proliferative lesions were observed on the first kidney specimen in two patients and in a further renal biopsy in four other patients, leading to a less favorable course of lupus nephropathy.

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“…We are presenting a rare case of PF‐like lesions in an adult patient with underlying APS. To our knowledge, this is the first case describing PF in an adult patient with APS 4,5 . The clinicians should be aware of this rare presentation of APS with PF‐like lesions and promptly perform a work‐up to exclude it.…”

mentioning

confidence: 78%

Antiphospholipid antibody syndrome presenting with purpura fulminans

et al. 2013

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties. Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. ABSTRACT Abstract is not required for Clinical Images (This page in not part of the published article.)

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Unusual and aggressive thrombotic onset in two children with antiphospholipid-antibody syndrome and systemic lupus erythematosus

Cited by 5 publications

References 19 publications

Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system

Clinical, laboratory and neuroimage findings in juvenile systemic lupus erythematosus presenting involvement of the nervous system

Prognosis of lupus membranous nephropathy in children

Antiphospholipid antibody syndrome presenting with purpura fulminans

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