Unusual Gallbladder Metastasis From Non–Small-Cell Lung Cancer Detected by F-18 FDG PET/CT With Intravenous Contrast Enhancement

Jeong, Hyeon Tae; Yun, Mijin; Hong, Hye Suk; Lee, Jong Doo; Kim, Ki Whang

doi:10.1097/rlu.0b013e3181e4dd2f

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…Autopsy findings reported by Abrams, et al indicated involvement of the gallbladder in 1.9% of lung cancer patients [2] . To the best of our knowledge, only three cases of clinical NSCLC metastasis to the gallbladder have been reported in the English language literature [3][4][5] Case No.…”

Section: Discussionmentioning

confidence: 99%

“…; these cases, along with the present case, are summarized in Table 1. Jeong HT, et al [4] Jeong Y, et al [5] NSCLC: non-small cell lung cancer; NA: not available; TTF-1: thyroid transcription factor-1; CK: cytokeratin; LN: lymph node.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is no "lung-specific tumor marker", TTF-1 can be used to discriminate between a primary lung tumor and a primary gallbladder tumor with a reasonable degree of certainty [12] . Two patients with gallbladder metastases of NSCLC were diagnosed by immunohistochemical TTF-1 positivity [4,5] Since it is a rare metastatic site, treatment options for metastatic tumors within the gallbladder are not clear. Whether the gallbladder tumor is primary or secondary, cholecystectomy is necessary in patients with symptomatic gallbladder to avoid symptoms or complications.…”

Section: Discussionmentioning

confidence: 99%

“…Extrathoracic metastatic disease is found at autopsy in >50% of patients with squamous cell carcinoma and 80% of patients with adenocarcinoma and large cell carcinoma [1] . By contrast, gallbladder metastasis is extremely rare in NSCLC patients: the gallbladder was recognized as a site of metastasis in only 1.9% of 160 lung cancer cases in large autopsy reviews [2] , and there are only a few clinical reports of cases in which metastatic lung cancer of the gallbladder  was detected when the patients were alive [3][4][5] A 79-year-old man presented in January, 2010 with a 3-day history of progressively worsening abdominal pain in the right upper quadrant, fever and headache. He had no relevant previous medical history.…”

Section: Introductionmentioning

confidence: 99%

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Gallbladder metastasis of non-small cell lung cancer presenting as acute cholecystitis

Jeong¹,

Han

Lim

et al. 2012

Chin. J. Cancer Res.

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Although non-small cell lung cancer (NSCLC) can metastasize to almost any organ, metastasis to the gallbladder with significant clinical manifestation is relatively rare. Here, we report a case of gallbladder metastasis of NSCLC presenting as acute cholecystitis. A 79-year-old man presented with pain in the right upper quadrant and fever. A computed tomography (CT) scan of the chest and abdomen showed a cavitary mass in the right lower lobe of the lung and irregular wall thickening of the gallbladder. Open cholecystectomy and needle biopsy of the lung mass were performed. Histological examination of the gallbladder revealed a moderately-differentiated squamous cell carcinoma displaying the same morphology as the lung mass assessed by needle biopsy. Subsequent immunohistochemical examination of the gallbladder and lung tissue showed that the tumor cells were positive for P63 but negative for cytokeratin 7, cytokeratin 20 and thyroid transcription factor-1. A second primary tumor of the gallbladder was excluded by immunohistochemical methods, and the final pathological diagnosis was gallbladder metastasis of NSCLC. Although the incidence is extremely rare, acute cholecystitis can occur in association with lung cancer metastasis to the gallbladder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gallbladder metastasis of non-small cell lung cancer presenting as acute cholecystitis

Jeong¹,

Han

Lim

et al. 2012

Chin. J. Cancer Res.

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“…Due to the hematogenous diffusion to the gallbladder, GM initially occur as small flat nodules below the mucosal layer and then grow as pedunculated nodules [47]. Usually GM are large hyperechoic (US) or hyperdense broad-based lesions (CT), greater than 1 cm in diameter and rarely associated with gallstones [54][55][56].…”

Section: Lung Cancermentioning

confidence: 99%

Imaging of gallbladder metastasis

et al. 2021

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Gallbladder metastasis (GM) is a rare condition, often with a late diagnosis or detected upon autopsy. There is no extensive literature on the imaging diagnosis of GM. Here we present a comprehensive review of the literature with the aim of helping to interpret the clinical findings and imaging features of such patients. Few studies on GM are reported in literature. GM by melanoma accounts for about 55.6% of cases. The remaining cases origin from breast cancer (13.6%), hepatocellular carcinoma (13.6%), renal cell carcinoma (6.8%), lung cancer (4.5%), lymphoma (3.5%) and gastric cancer (2.4%). The most common clinical presentation of GM is abdominal pain from cholecystitis due to obstruction of the cystic duct. The main ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) findings that clinicians and radiologists should consider in their everyday medical activity were discussed. The diagnosis of GM was often achieved through a combination of more than one imaging modality. In more than 90% of cases, the diagnosis of GM is often late and combined with other organs involvement in the terminal stage of the malignancy. The knowledge of the clinical features and different imaging techniques through careful evaluation of the gallbladder can help to achieve early diagnosis and avoid misdiagnosis or false negative results.

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