Unusual late metastasis from gastric carcinoma

Martí, Juan; Sainz, Marta

doi:10.4103/1319-3767.87188

Cited by 3 publications

(5 citation statements)

References 4 publications

(6 reference statements)

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“…Lymphatic metastases first occur to regional and latter to the distant lymph nodes; peritoneal carcinomatosis is the most common site of distant metastasis, followed by the liver, lungs and bones 5 . Bone metastases are found between 1% and 20% of cancers of the stomach 5,7-9 , and are mainly osteolytic, while osteoblastic implants are considered rare [5][6][7][8][9][10] .…”

Section: Discussionmentioning

confidence: 99%

“…Bone metastasis associated with gastric cancer is considered a relatively uncommon phenomenon 4,5 , and has been related to poorer prognosis 6,9 , in special if implants occur in multiple areas 6,8,9 .…”

Section: Discussionmentioning

confidence: 99%

“…Asymptomatic bone implants occur in up to 20% of the patients with gastric cancer, but main symptoms are pain, fractures, and paraplegia 9 .…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory tests indicative of gastric cancer with bone metastasis include high serum levels of alkaline phosfatase, CA 19-9 and CEA [6][7][8][9] .…”

Section: Discussionmentioning

confidence: 99%

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Infiltrating gastric adenocarcinoma with disseminated osteoblastic metastases

Santos

Vieira²,

Marinho³

et al. 2013

Anales Sis San Navarra

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We report the case of a man with a diagnosis of invasive gastric adenocarcinoma associated with scattered osteoblastic metastases. This 65-year-old patient was admitted with nausea, vomiting and abdominal pain, in addition to loss of weight (13 Kg in 3 months). Upper digestive endoscopy revealed extensive infiltrating changes in the body of the stomach, and histopathologic data confirmed the diagnosis of a Borrmann IV gastric adenocarcinoma. Complementary exams were indicative of a gastric cancer with bone metastases, characterized by disseminated osteoblastic images of the scintigraphy of the skeleton. Palliative chemotherapy was the treatment of first choice. High serum levels of CA 19-9, CEA and alkaline phosphatase can constitute useful indicative tools of this challenging condition. Images from a scintigraphy study of the skeleton can characterize the type and extension of bone metastases. The aim of this case study is to report a case of a very uncommon condition, considering that disseminated osteoblastic metastases rarely develop in this kind of tumor.Key words. Adenocarcinoma. Bone metastasis. Gastric tumor. RESUMENPresentamos un caso de adenocarcinoma gástri-co infiltrante asociado con metástasis osteoblásticas diseminadas. Un paciente de 65 años ingresó con náu-seas, vómitos y dolor abdominal asociados con pérdida de peso (13 Kg en 3 meses). La endoscopia digestiva objetivó extensas alteraciones infiltrativas del cuerpo gástrico y los datos histopatológicos confirmaron el diagnóstico de adenocarcinoma gástrico Borrmann IV. Exámenes complementarios fueran indicativos de cán-cer gástrico con metástasis óseas, caracterizadas por imágenes osteoblásticas diseminadas de la cintilografía del esqueleto. Se le administró quimioterapia paliativa como primera opción. Se elevó CA 19-9, CEA y apareció fosfatasis alcalina en el suero un indicador útil del diagnóstico. La extensión y el tipo de metástasis óseas pueden ser imágenes de cintilografías del esqueleto. Este caso tiene como objetivo describir la presencia de metástasis osteoblásticas diseminadas que raramente son producidas por este tipo de tumor.Palabras clave. Adenocarcinoma. Metástasis óseas. Tumor gástrico.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Infiltrating gastric adenocarcinoma with disseminated osteoblastic metastases

Santos

Vieira²,

Marinho³

et al. 2013

Anales Sis San Navarra

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“…(10) the mortality rate is attributed to the patients' late presentation in addition to the high lethal nature of the disease.Moreover, bone metastasisrarely present as a primary presentation of gastric malignancy. (11) this is due to the fact that bone metastasis from gastric cancer present as a late stage or as a recurrence. The prognosis of patients with bone metastases is poor, the median survival rate is about 5 months after the appearance of bone lesions, and 3.5 years has been the longest survival period reported in the literature.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%

Case Report of 64-Year-Old Male Patient With Gastric Adenocarcinoma Presented as Pathological Neck of Femur Fracture

Altowairqi¹,

Felemban²,

Alharbi³

et al. 2020

IJAR

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Targeting mast cells in gastric cancer with special reference to bone metastases

Leporini¹

2015

WJG

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Bone metastases from gastric cancer (GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells (MCs) positive to tryptase (MCPT) in primary gastric tumor angiogenesis. Recently, we analyzed infiltrating MCs and neovascularization in bone tissue metastases from primary GC patients, and observed a significant correlation between infiltrating MCPT and angiogenesis. Such a finding suggested the involvement of peritumoral MCPT by infiltrating surrounding tumor cells, and in bone metastasis angiogenesis from primary GC. Thus, an MCPT-stimulated angiogenic process could support the development of metastases in bone tissue. From this perspective, we aim to review the hypothetical involvement of tumor-infiltrating, peritumoral MCPT in angiogenesis-mediated GC cell growth in the bone microenvironment and in tumor-induced osteoclastic bone resorption. We also focus on the potential use of MCPT targeting agents, such as MCs tryptase inhibitors (gabexate mesylate, nafamostat mesylate) or c-KitR tyrosine kinase inhibitors (imatinib, masitinib), as possible new anti-angiogenic and anti-resorptive strategies for the treatment of GC patients affected by bone metastases.

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Unusual late metastasis from gastric carcinoma

Cited by 3 publications

References 4 publications

Infiltrating gastric adenocarcinoma with disseminated osteoblastic metastases

Infiltrating gastric adenocarcinoma with disseminated osteoblastic metastases

Case Report of 64-Year-Old Male Patient With Gastric Adenocarcinoma Presented as Pathological Neck of Femur Fracture

Targeting mast cells in gastric cancer with special reference to bone metastases

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