Unusual Ocular Involvement in Acute Lymphatic Leukemia

O'Rourke, J.; O, Connor G. Richard

doi:10.1001/archopht.1957.00930050597013

Cited by 20 publications

(8 citation statements)

References 7 publications

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“…Conjunctival leukaemic infiltration responds well to systemic chemotherapy. 84 A prompt recognition of the ocular manifestation and their importance as a sign of possible extramedullary disease is crucial if appropriate therapy is to be initiated.…”

Section: Treatment Of Leukaemic Eye Infiltratesmentioning

confidence: 99%

Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role

Sharma

Grewal

Gupta

et al. 2004

Eye

210

166

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With evolving diagnostic and therapeutic advances, the survival of patients with acute leukaemia has considerably improved. This has led to an increase in the variability of ocular presentations in the form of side effects of the treatment and the ways leukaemic relapses are being first identified as an ocular presentation. Leukaemia may involve many ocular tissues either by direct infiltration, haemorrhage, ischaemia, or toxicity due to various chemotherapeutic agents. Ocular involvement may also be seen in graft-versushost reaction in patients undergoing allogeneic bone marrow transplantation, or simply as increased susceptibility to infections as a result of immunosuppression that these patients undergo. This can range from simple bacterial conjunctivitis to an endophthalmitis. Leukaemia can present as pathology in the adnexae, conjunctiva, sclera, cornea, anterior chamber, iris, lens, vitreous, retina, choroid, and optic nerve. Recognition of the varied ocular presentations is also important in assessing the course and prognosis of leukaemia. We have presented a systematic approach taking each part of the eye in turn and outlining how leukaemia has been shown to affect it.

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Section: Treatment Of Leukaemic Eye Infiltratesmentioning

confidence: 99%

Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role

Sharma

Grewal

Gupta

et al. 2004

Eye

210

166

View full text Add to dashboard Cite

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“…It may present as retinal changes such as hemorrhages [16][17][18], whitish infiltrates often resembling cotton wool spots [16][17][18], peripheral ret inal microaneurysms [19,20] or peripheral retinal neo vascularization [21,22], Clinically, leukemic choroidal in filtrates frequently remain undetected but may present as serous retinal detachment [23,24], Leukemic iris infil tration [25,26], optic nerve infiltration [27,28], vitreous seeding [29], orbital involvement [3,30], and conjunctival infiltration [31] may also occur. Allen and Straatsma [32], in a histopathologic study, found ocular involvement in 38 of 76 eyes of patients who had died of leukemia or allied disorders.…”

Section: Discussionmentioning

confidence: 99%

Necrotic Malignant Melanoma of the Choroid and Concurrent Intraocular Manifestation of Malignant Non-Hodgkin’s B Cell Lymphoma

Küchle

Tiemann²,

Holbach³

et al. 1994

Ophthalmologica

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An 80-year-old white female developed clinical signs of a large choroidal malignant melanoma in her left eye. There were no signs of metastatic disease but an asymptomatic chronic lymphatic leukemia was discovered. Histopathologic examination of the enucleated left eye showed a mostly necrotic malignant melanoma of the choroid with areas of spindle B cell differentiation, episcleral extension and secondary angle-closure glaucoma with necrosis of the anterior segment of the eye. On the basis of immunocytochemical studies of the lymphocytic infiltrates in the iridal blood vessels, retinal blood vessels and the choroid, the leukemic disease was classified as B cell lymphoma of low malignancy (lymphoplasmacytoid immunocytoma). A reactive T lymphocytic infiltration of the conjunctival stroma was also noted. Patients with malignant melanomas of the uvea require exclusion of a second malignancy.

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“…Таким образом, про-водить адекватное лечение глазного яблока только с помощью системной терапии невозможно [83]. Исключением является конъюнктивальная лейке-мическая инфильтрация, которая хорошо отвеча-ет на системную химиотерапию [82]. Ellis и Little продемонстрировали, что даже химиопрепараты, введённые интратекально, не попадают в необ-ходимой дозировке внутрь глаза.…”

Section: лечение лейкемической инфильтрации глазunclassified

“…Исследовате-ли считают, что инфильтрация ретробульбарной части зрительного нерва является более угрожа-ющей для зрения, чем инфильтрация диска, хотя состояния могут сосуществовать. Вовлечение орбиты в лейкемический процесс имеет плохой прогноз, даже несмотря на облучение и химио-терапию [82]. Незамедлительная диагностика офтальмологических изменений и определение степени их значимости как возможных признаков экстрамедуллярного развития заболевания явля-ется крайне важной для своевременного начала лечения.…”

Section: лечение лейкемической инфильтрации глазunclassified

Ophthalmic manifestation of leukemia

Chistyakova

Викторовна²

2016

Ophthalmology Reports

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ОфтальмОлОгические ПрОЯвлениЯ леЙкОЗОвG This paper includes a literature review on the ophthalmic manifestations of leukemia. Various eye disorder types in leukemia with concurrent anemia, hypoxia, increased blood viscosity, as well as the compression of tissues by tumor cells conglomerates and/or presence of direct leukemic infiltration were considered. Ophthalmic diseases in patients with hematological malignancies may occur due to opportunistic infections and the impact of such treatments as chemotherapy, radiotherapy and bone marrow transplantation. Reliable estimation of eye involvement rates in leukemic process is difficult, as many patients are asymptomatic at early stages of the disease. However, the predictive value of visual impairment assessment in leukemia is high, which requires close cooperation between ophthalmologists and hematologists, and appropriate adjustment of both local and systemic therapies.G

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Unusual Ocular Involvement in Acute Lymphatic Leukemia

Cited by 20 publications

References 7 publications

Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role

Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role

Necrotic Malignant Melanoma of the Choroid and Concurrent Intraocular Manifestation of Malignant Non-Hodgkin’s B Cell Lymphoma

Ophthalmic manifestation of leukemia

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