Unusual Sacrococcygeal Embryologic Malformations With Cutaneous Manifestations

Harrist, Terence J.

doi:10.1001/archderm.1982.01650210023011

Cited by 24 publications

(3 citation statements)

References 13 publications

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“…Regression of a portion of the distal (caudal) neural tube (retrogression differentiation) formed during the canalization of the neural tube results in the formation of the ventriculus terminalis, the filum terminalis, and the coccygeal medullary vestige. 15 Incomplete regression or focal premature dysjunction of the distal neural tube may be an important factor in the disturbance of human tail development. The gelatinous tip (denuded skin area) of the tail as seen in our case probably represents a cyst of the coccygeal medullary vestige that ruptured soon after birth.…”

Section: Discussionmentioning

confidence: 99%

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A Gelatinous Human Tail With Lipomyelocele

et al. 2012

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We report a female infant who presented with a tail appendage bearing a gelatinous tip and an associated lipomyelocele. Magnetic resonance images revealed the presence of spina bifida and a tract in continuity from the tail to the conus medullaris. The tail was surgically removed. A human tail may be associated with underlying spinal dysraphism. Magnetic resonance or computed tomographic imaging is required in such cases for complete evaluation. This is the first case report of gelatinous-tip human tail.

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Section: Discussionmentioning

confidence: 99%

“…There is 1 previous case report of an infant with a cystic dilation of the coccygeal medullary vestige. 15 Sonic hedgehog (Shh) has been implicated in the growth of cutaneous appendages such as hair, feathers, or scales. The sonic hedgehog is an important protein in the embryonic development of the notochord.…”

Section: Discussionmentioning

confidence: 99%

A Gelatinous Human Tail With Lipomyelocele

et al. 2012

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“…Midline or near midline sacrococcygeal cutaneous lesions may indicate malformations of the spinal canal and its body covering (spina bifida). Such lesions include dimples, sinuses, skin tags, pigmented macules, sacral hypertrichosis (fawn tail), lipomas, hemangiomas, bony masses, and epidermal nevus (4). In a review of 200 cases in the literature, 51% of occult spinal dysraphism cases were associated with single (61%) or multiple (39%) sacrococcygeal cutaneous lesions (5).…”

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confidence: 99%