Unusual twinning: Additional findings during prenatal diagnosis of twin zygosity by single nucleotide polymorphism (SNP) array

Zou, Zhiyong; Huang, Liwu; Lin, Shaobin; He, Zhiming; Luo, Yang

doi:10.1002/pd.5255

Cited by 10 publications

(4 citation statements)

References 35 publications

(60 reference statements)

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“…14 The existence of monochorionicity for dizygotic twins has traditionally been viewed as rare although more recent studies suggest this may be more frequently encountered, especially when there has been assisted reproduction. 15 Monozygotic (“identical”) twins are the consequence of an early splitting of the cells derived from a single fertilized egg and the presentation of the extra‐embryonic tissues will be dependent on the timing of the split. Very early separation (morula stage) will result in dichorionic diamniotic tissues (i.e., the same as that seen in a dizygotic twin pregnancy).…”

Section: Zygosity and Chorionicitymentioning

confidence: 99%

“…Dizygotic (“non‐identical”) twins are the product of two egg fertilizations and these pregnancies will generally have dichorionic diamniotic extra‐fetal tissues 14 . The existence of monochorionicity for dizygotic twins has traditionally been viewed as rare although more recent studies suggest this may be more frequently encountered, especially when there has been assisted reproduction 15 . Monozygotic (“identical”) twins are the consequence of an early splitting of the cells derived from a single fertilized egg and the presentation of the extra‐embryonic tissues will be dependent on the timing of the split.…”

Section: Zygosity and Chorionicitymentioning

confidence: 99%

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Non‐invasive prenatal testing in the management of twin pregnancies

Benn

Rebarber

2021

Prenatal Diagnosis

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Twin pregnancies are common and associated with pregnancy complications and adverse outcomes. Prenatal clinical management is intensive and has been hampered by inferior screening and less acceptable invasive testing. For aneuploidy screening, meta-analyses show that non-invasive prenatal testing (NIPT) through analysis of cell-free DNA (cf-DNA) is superior to serum and ultrasound-based tests.The positive predictive value for NIPT is driven strongly by the discriminatory power of the assay and only secondarily by the prior risk. Uncertainties in a priori risks for aneuploidies in twin pregnancies are therefore of lesser importance with NIPT.Additional information on zygosity can be obtained using NIPT. Establishing zygosity can be helpful when chorionicity was not reliably established early in pregnancy or where the there is a concern for one versus two affected fetuses. In dizygotic twin pregnancies, individual fetal fractions can be measured to ensure that both values are satisfactory. Vanishing twins can be identified by NIPT. Although clinical utility of routinely detecting vanishing twins has not yet been demonstrated, there are individual cases where cf-DNA analysis could be helpful in explaining unusual clinical or laboratory observations. We conclude that cf-DNA analysis and ultrasound have synergistic roles in the management of multiple gestational pregnancies. Key PointsWhat's already known about this topic? � In singleton pregnancies, non-invasive prenatal testing (NIPT) for fetal aneuploidy is more effective than conventional serum and ultrasound-based screening tests.� NIPT is more complex in dizygotic twin pregnancies due to the presence of two fetal genotypes.� Overall fetal fraction is higher in twin pregnancies but the individual contribution for each fetus is lower. What does this study add?� A review of cell-free DNA testing in twin pregnancies.� Individual fetal fractions in dizygotic twin pregnancies can be measured.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Zygosity and Chorionicitymentioning

confidence: 99%

Section: Zygosity and Chorionicitymentioning

confidence: 99%

Non‐invasive prenatal testing in the management of twin pregnancies

Benn

Rebarber

2021

Prenatal Diagnosis

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“…Our fourth‐place runner‐up is Zhiyong Zou, for Unusual twinning: Additional findings during prenatal diagnosis of twin zygosity by single nucleotide polymorphism (SNP) array, from our May issue.…”

Section: The Malcolm Ferguson‐smith Award: Winning Authors and Articlesmentioning

confidence: 99%

The 2018 Malcolm Ferguson‐Smith Young Investigator Award

et al. 2019

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“…Single nucleotide polymorphism (SNP) array is a procedure performed during prenatal diagnosis (Zou et al, 2017). Specifically, it can evaluate copy number variations (repeated sections of the genome) and uniparental disomy (receipt of two copies of a certain chromosome from one parent), but its benefits for twin zygosity diagnosis have been underappreciated.…”

Section: Unusual Twinningmentioning

confidence: 99%

Twins Switched at Birth: Frequency, Life Histories, Twin Relationships, and Critical Issues/Twin Research Reviews: Classroom Placement; Mirror Syndrome; Unusual Twinning; Parenting Stress/Human Interest: Triplet Film; Educational Achievement; Prison Release; Co-Twin Impersonation; Facial Recognition Technology

Segal

2018

Twin Res Hum Genet

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Twins switched at birth are a rare subtype of twins who grow up apart. The frequency with which this event occurs, as well as selected life history events, twin relationships, and critical issues generated by the nine recorded cases are reviewed. This is followed by summaries of recent studies addressing classroom placement for twins, mirror syndrome in mothers, unusual twin types, and parenting stress. The article concludes with a review of human interest items from the general media, namely a triplet film, educational achievement, prison release, co-twin impersonation, and facial recognition technology.

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Unusual twinning: Additional findings during prenatal diagnosis of twin zygosity by single nucleotide polymorphism (SNP) array

Cited by 10 publications

References 35 publications

Non‐invasive prenatal testing in the management of twin pregnancies

Non‐invasive prenatal testing in the management of twin pregnancies

The 2018 Malcolm Ferguson‐Smith Young Investigator Award

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