Unusual Urethral F18-FDG Accumulation on PET/CT

Abstract

Normal physiological variants of F-18 fluorodeoxyglucose (FDG) distribution and benign findings on whole-body FDG PET scans are well described in the medical literature. In this report, an 82-year-old man presented with laryngeal cancer and an unusual variant of urinary FDG activity in the prostatic urethra. Beside the FDG uptake in the laryngeal mass and neck lymph nodes, PET/CT images demonstrate FDG accumulation in the prostatic urethra because of the dilatation of this part of the urethra, possibly because of previous open prostatectomy.

Initial Staging and Response Evaluation With 18F-FDG PET/CT in a Rare Case of Nested Variant Urothelial Urethral Cancer

“…[4][5][6][7] Although there are no published studies on the role of 18 F-FDG PET/CT imaging in patients with primary urothelial urethral cancer, previous articles have reported on the uptake of FDG in the urethra due to metastases from other cancers, inflammation, and normal variation. [8][9][10][11] Early detection and effective management with 18 F-FDG PET/CT imaging can offer significant help in detecting small tumors that may not be visible through other diagnostic methods. 12 Despite the uncertainty surrounding the management of urothelial urethral cancer due to its rarity, a combination of 18 F-FDG PET/CT with other diagnostic methods such as contrast-enhanced CT scan and MRI can accurately identify the location of the tumor and the extent of tissue involvement, allowing physicians to choose the best treatment option and avoid recurrence.…”

“…Nested variant urothelial carcinoma of the urethra is an even rarer and more aggressive form of this cancer 4–7 . Although there are no published studies on the role of 18 F-FDG PET/CT imaging in patients with primary urothelial urethral cancer, previous articles have reported on the uptake of FDG in the urethra due to metastases from other cancers, inflammation, and normal variation 8–11 . Early detection and effective management with 18 F-FDG PET/CT imaging can offer significant help in detecting small tumors that may not be visible through other diagnostic methods 12 .…”

18F-FDG PET/CT Findings of Metastasis to Spongy Body of Penis From Urothelial Carcinoma of Bladder

“…1-8 18 F-FDG uptake in the penis has been described in conditions such as primary malignancy of the penis, lymphoma, and dilated urethra. [9][10][11][12][13] Metastatic tumors of the penis have been previously described but are rare. 14 18 F-FDG accumulation in the penis has been described in a very few cases of metastatic malignancy and lymphoma.…”