Unveiling antimicrobial and anticancerous behavior of AuNPs and AgNPs moderated by rhizome extracts of Curcuma longa from diverse altitudes of Himalaya

Sharma, Mamta; Monika, .; Thakur, Pankaj; Saini, Reena V.; Kumar, Rajesh; Torino, Enza

doi:10.1038/s41598-020-67673-4

Cited by 24 publications

(13 citation statements)

References 30 publications

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“…Some more studies further observed concentration-dependent bactericidal efficacy of AuNPs. It was also demonstrated that AuNPs in the concentration range of 50-300 µg/ml exhibited good zone of inhibition against B. subtilis (15.33+ 0.57 to 20.01+0.01) and E. coli (12.00+0.57 to 16.66+0.57) (58). Similarly, AuNPs were observed to exert bactericidal effect against S. aureus (10.0 to 30.0 mm) and E. coli (16.0 to 25.0 mm) at the concentration of 100-200 µg/ml (50).…”

Section: Ecolimentioning

confidence: 92%

Phytofabrication of gold and bimetallic gold-silver nanoparticles using water extract of wheatgrass (Triticum aestivum), their characterization and comparative assessment of antibacterial potential

Pahal

Kumar

et al. 2022

Plant Sci. Today

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In the present study, gold (AuNPs) and gold-silver bimetallic nanoparticles (Au-Ag BMNPs) were fabricated by using water extract of leaves of Triticum aestivum - a crop plant, and their bactericidal potency was checked against selected pathogenic bacterial strains. The phytofabricated AuNPs and BMNPs were analyzed for their physical attributes using UV–Visible and Fourier transformed infrared spectroscopy, Dynamic light scattering, High-resolution transmission electron microscopy, Energy-dispersive X-ray spectroscopy. HRTEM analysis revealed that both kinds of NPs were highly crystalline in nature and of spherical and oval-shaped. AuNPs size was found in the range of 5-40 nm, whereas BMNPs showed their size in the range of 5-30 nm. HRTEM results were corroborated by DLS results which revealed the average hydrodynamic diameter of AuNPs and BMNPs in the range of 29.08 and 26.56 nm, respectively. UV-visible spectroscopy showed high-intensity single spectral peaks at 540 and 480 nm for AuNPs and BMNPs, respectively. FTIR analysis demonstrated that protein, flavanones, hydroxyl, carboxylate groups, and reducing sugars were responsible for reducing and capping of both NPs. Bactericidal efficiency of synthesized NPs was evaluated using agar-well diffusion and XTT-colorimetric assays against K. pneumoniae, S. typhimurium, E. aerogenes, E. coli, M. luteus, S. aureus, S. mutans and S. epidermidis. K. pneumonia and S. typhimurium were found to be the most sensitive bacteria towards BMNPs-mediated (MIC: 400 µg/ml) and AuNPs-mediated toxicity (MIC: 800 µg/ml). It was observed that BMNPs generally possessed more powerful bactericidal effect against all bacterial strains in comparison to AuNPs. MIC and MBC values were observed in the concentration range of 400 µg/ml-1.5 mg /ml for different bacterial strains. Furthermore, it was demonstrated that phytosynthesized AuNPs have their own bactericidal effect, but at higher concentrations (>100 µg/ml), and bactericidal effect of BMNPs was due to the synergistic effect of both Ag and Au ions, which was also observed to be concentration-dependent.

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Section: Ecolimentioning

confidence: 92%

Phytofabrication of gold and bimetallic gold-silver nanoparticles using water extract of wheatgrass (Triticum aestivum), their characterization and comparative assessment of antibacterial potential

Pahal

Kumar

et al. 2022

Plant Sci. Today

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“…Further, silver ions can link with thiol groups of biomolecules and with phosphorus sulfide compounds, such as when DNA inactivates bacteria. Many studies concerning AgNPs' antimicrobial activity have been published (Alafeef, Moitra, & Pan, 2020; Devanesan, Ponmurugan, AlSalhi, & Al‐Dhabi, 2020; Elmehbad & Mohamed, 2020; Garibo et al, 2020; Rao, Saptami, Venkatesan, & Rekha, 2020; Sharma et al, 2020; Taghavizadeh Yazdi et al, 2020).…”

Section: Agnps: In Vitro and In Vivo Studiesmentioning

confidence: 99%

Silver nanoparticles as a potential treatment against SARS‐CoV‐2: A review

Pilaquinga

Morey

Arias

et al. 2021

WIREs Nanomed Nanobiotechnol

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Several human coronaviruses (HCoVs) are distinguished by the ability to generate epidemics or pandemics, with their corresponding diseases characterized by severe respiratory illness, such as that which occurs in severe acute respiratory syndrome (SARS‐CoV), Middle East respiratory syndrome (MERS‐CoV), and, today, in SARS‐CoV‐2, an outbreak that has struck explosively and uncontrollably beginning in December 2019 and has claimed the lives of more than 1.9 M people worldwide as of January 2021. The development of vaccines has taken one year, which is why it is necessary to investigate whether some already‐existing alternatives that have been successfully developed in recent years can mitigate the pandemic's advance. Silver nanoparticles (AgNPs) have proved effective in antiviral action. Thus, in this review, several in vitro and in vivo studies of the effect of AgNPs on viruses that cause respiratory diseases are analyzed and discussed to promote an understanding of the possible interaction of AgNPs with SARS‐CoV‐2. The study focuses on several in vivo toxicological studies of AgNPs and a dose extrapolation to humans to determine the chief avenue of exposure. It can be concluded that the use of AgNPs as a possible treatment for SARS‐CoV‐2 could be viable, based on comparing the virus' behavior to that of similar viruses in in vivo studies, and that the suggested route of administration in terms of least degree of adverse effects is inhalation. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Respiratory Disease Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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“…The β-asarone is able to retard the metabolic transformations and glucose intolerance, to reduce the body weight, cholesterol level in adipose tissue in mice. The lipid-lowering effect has been observed with water extract of sweet flag [ 844 , 845 ]…”

Section: Health Benefit Potentialmentioning

confidence: 99%

Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology

Mandal

Sarkar

Chakraborty

2022

Appl Biochem Biotechnol

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Medicinal or herbal spices are grown in tropical moist evergreen forestland, surrounding most of the tropical and subtropical regions of Eastern Himalayas in India (Sikkim, Darjeeling regions), Bhutan, Nepal, Pakistan, Iran, Afghanistan, a few Central Asian countries, Middle East, USA, Europe, South East Asia, Japan, Malaysia, and Indonesia. According to the cultivation region surrounded, economic value, and vogue, these spices can be classified into major, minor, and colored tropical spices. In total, 24 tropical spices and herbs (cardamom, black jeera, fennel, poppy, coriander, fenugreek, bay leaves, clove, chili, cassia bark, black pepper, nutmeg, black mustard, turmeric, saffron, star anise, onion, dill, asafoetida, celery, allspice, kokum, greater galangal, and sweet flag) are described in this review. These spices show many pharmacological activities like anti-inflammatory, antimicrobial, anti-diabetic, anti-obesity, cardiovascular, gastrointestinal, central nervous system, and antioxidant activities. Numerous bioactive compounds are present in these selected spices, such as 1,8-cineole, monoterpene hydrocarbons, γ-terpinene, cuminaldehyde, trans-anethole, fenchone, estragole, benzylisoquinoline alkaloids, eugenol, cinnamaldehyde, piperine, linalool, malabaricone C, safrole, myristicin, elemicin, sinigrin, curcumin, bidemethoxycurcumin, dimethoxycurcumin, crocin, picrocrocin, quercetin, quercetin 4’-O-β-glucoside, apiol, carvone, limonene, α-phellandrene, galactomannan, rosmarinic acid, limonene, capsaicinoids, eugenol, garcinol, and α-asarone. Other than that, various spices are used to synthesize different types of metal-based and polymer-based nanoparticles like zinc oxide, gold, silver, selenium, silica, and chitosan nanoparticles which provide beneficial health effects such as antioxidant, anti-carcinogenic, anti-diabetic, enzyme retardation effect, and antimicrobial activity. The nanoparticles can also be used in environmental pollution management like dye decolorization and in chemical industries to enhance the rate of reaction by the use of catalytic activity of the nanoparticles. The nutritional value, phytochemical properties, health advantages, and both traditional and modern applications of these spices, along with their functions in food fortification, have been thoroughly discussed in this review

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Unveiling antimicrobial and anticancerous behavior of AuNPs and AgNPs moderated by rhizome extracts of Curcuma longa from diverse altitudes of Himalaya

Cited by 24 publications

References 30 publications

Phytofabrication of gold and bimetallic gold-silver nanoparticles using water extract of wheatgrass (Triticum aestivum), their characterization and comparative assessment of antibacterial potential

Phytofabrication of gold and bimetallic gold-silver nanoparticles using water extract of wheatgrass (Triticum aestivum), their characterization and comparative assessment of antibacterial potential

Silver nanoparticles as a potential treatment against SARS‐CoV‐2: A review

Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology

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