Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

Fang, Wen-Kai; Wei, Yanchun

doi:10.1142/s1793545816300068

Cited by 27 publications

(13 citation statements)

References 142 publications

(131 reference statements)

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“…The fast moving field of lanthanide‐containing luminescent nanoparticles has been the subject of many recent reviews covering subjects as diverse as fundamental properties, synthesis, biosensing, bioimaging, drug delivery and theranostics, as well as persistent luminescence nanoparticles, NIR‐emitting nanoparticles, and forensic or other applications . The present review focuses on biological/medical applications and on lighting/displays, two main sectors in which nanomaterials have brought significant advances recently.…”

Section: Introductionmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

Small

145

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Half a century after its initial emergence, lanthanide photonics is facing a profound remodeling induced by the upsurge of nanomaterials. Lanthanide-doped nanomaterials hold promise for bioapplications and photonic devices because they ally the unmatched advantages of lanthanide photophysical properties with those arising from large surface-to-volume ratios and quantum confinement that are typical of nanoobjects. Cutting-edge technologies and devices have recently arisen from this association and are in turn promoting nanophotonic materials as essential tools for a deeper understanding of biological mechanisms and related medical diagnosis and therapy, and as crucial building blocks for next-generation photonic devices. Here, the recent progress in the development of nanomaterials, nanotechnologies, and nanodevices for clinical uses and commercial exploitation is reviewed. The candidate nanomaterials with mature synthesis protocols and compelling optical uniqueness are surveyed. The specific fields that are directly driven by lanthanide doped nanomaterials are emphasized, spanning from in vivo imaging and theranostics, micro-/nanoscopic techniques, point-of-care medical testing, forensic fingerprints detection, to micro-LED devices.

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Section: Introductionmentioning

confidence: 99%

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Zhou

Leaño

Liu³

et al. 2018

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145

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“…The traditional methods for treatment of cancer include surgical excision, radiation therapy and chemotherapy 40 , 41 . Recently, with the development of modern technology, other treatment methods have also been studied such as angiogenesis inhibitors therapy 42 , 43 , immune therapy 44 - 47 , photodynamic therapy 48 - 50 , hyperthermia therapy 51 , and gene therapy 52 , 53 . The aim of diagnosis is to localize and characterize disorders at an early stage.…”

Section: Current Approaches V/s Nanotheranostics For Brain Cancermentioning

confidence: 99%

“…The materials are excited by absorbing low energy radiation at longer wavelength followed by emission of visible light with higher energy via multiphoton absorption. This property renders them more popular systems for nanotheranostic applications 43 . Since the biological tissues do not absorb NIR light of UCNPs, excitation of them does not cause photo damage.…”

Section: Nanotheranostic Platforms For Brain Cancer Applicationsmentioning

confidence: 99%

Nanotheranostics: Emerging Strategies for Early Diagnosis and Therapy of Brain Cancer

Sonali¹,

Viswanadh²,

Singh³

et al. 2018

Nanotheranostics

133

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Nanotheranostics have demonstrated the development of advanced platforms that can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In brain nanotheranostics, therapeutic as well as diagnostic entities are loaded in a single nanoplatform, which can be further developed as a clinical formulation for targeting various modes of brain cancer. In the present review, we concerned about theranostic nanosystems established till now in the research field. These include gold nanoparticles, carbon nanotubes, magnetic nanoparticles, mesoporous silica nanoparticles, quantum dots, polymeric nanoparticles, upconversion nanoparticles, polymeric micelles, solid lipid nanoparticles and dendrimers for the advanced detection and treatment of brain cancer with advanced features. Also, we included the role of three-dimensional models of the BBB and cancer stem cell concept for the advanced characterization of nanotheranostic systems for the unification of diagnosis and treatment of brain cancer. In future, brain nanotheranostics will be able to provide personalized treatment which can make brain cancer even remediable or at least treatable at the primary stages.

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“…19 Moreover, when used in biomedicine, UCNs show many advantages such as their superior photostability, nonblinking property, absence of autofluorescence of biological tissue and use of low-energy NIR radiation. 20,21 On the basis of the above merits, UCNs are ideal probes for real-time sensing of the eigen temperature of PTT agents in biological systems.…”

Section: Introductionmentioning

confidence: 99%

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

Wei¹,

Liu²,

Pan³

et al. 2020

IJN

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Background: Photothermal therapy with accurate and real-time temperature detection is desired in clinic. Upconversion nanocrystals (UCNs) are candidate materials for simultaneous temperature detection and photothermal agents carrying. However, the weak luminescence and multiple laser excitations of UCNs limit their application in thermal therapy. Materials and Methods: NaYF 4 :Yb 3+ ,Er 3+ ,Nd 3+ , PL-PEG-NH 2 , IR-806 and folic acid are selected as structural components. A nanoprobe (NP) integrated with efficient photothermal conversion and sensitive temperature detection capabilities is synthesized for precise photothermal therapy. The probes are based on near-infrared upconversion nanocrystals doped with Yb, Er and Nd ions, which can be excited by 808 nm light. IR-806 dye molecules are modified on the surface as molecular antennas to strongly absorb near-infrared photons for energy transfer and conversion. Results: The results show that under an 808 nm laser irradiation upconversion luminescence of the nanocrystals is enhanced based on both the Nd ion absorption and the FRET energy transfer of IR-806. The luminescence ratio at 520 and 545 nm is calculated to accurately monitor the temperature of the nanoparticles. The temperature of the nanoprobes increases significantly through energy conversion of the molecular antennas. The nanoparticles are found successfully distributed to tumor cells and tumor tissue due to the modification of the biocompatible molecules on the surface. Tumor cells can be killed efficiently based on the photothermal effect of the NPs. Under the laser irradiation, temperature at mouse tumor site increases significantly, tissue necrosis and tumor cell death can be observed. Conclusion: Precision photothermal therapy can thus be achieved by highly efficient nearinfrared light absorption and accurate temperature monitoring, making it promising for tumor treatment, as well as the biological microzone temperature detection.

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Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

Cited by 27 publications

References 142 publications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications

Nanotheranostics: Emerging Strategies for Early Diagnosis and Therapy of Brain Cancer

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

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