Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat, oxygen and reactive oxygen species for suppressing hypoxic tumors

Kim, Hanju; Yoon, Johyun; Kim, Hwang Kyung; Lee, Woo Tak; Nguyen, Nguyen Thi; Le, Xuan Thien; Lee, Eun Hee; Lee, Eun Seong; Oh, Kyung Taek; Choi, Han‐Gon; Youn, Yu Seok

doi:10.1016/j.bioactmat.2022.09.020

Cited by 12 publications

(13 citation statements)

References 65 publications

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“…However, the circulation time of free Hb is short, and its stability is poor, which limits its usage and application areas. To solve this problem, researchers have used various nanocarriers to load HbO 2 by physical encapsulation to achieve the same oxygen-carrying function as RBCs ( Jansman and Hosta-Rigau, 2018 ; Kim et al, 2023 ). A nanobionic oxygen carrier (DHCNPs) with the functions of targeting homologous cancer cells and increasing oxygen content was prepared by using polymer-loaded doxorubicin (DOX) and Hb as the core and coating of breast cancer cell membrane on the surface ( Tian et al, 2017 ).…”

Section: Nanomaterial-mediated Tumor Hypoxia Reliefmentioning

confidence: 99%

Nanotechnological strategies to increase the oxygen content of the tumor

et al. 2023

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Hypoxia is a negative prognostic indicator of solid tumors, which not only changes the survival state of tumors and increases their invasiveness but also remarkably reduces the sensitivity of tumors to treatments such as radiotherapy, chemotherapy and photodynamic therapy. Thus, developing therapeutic strategies to alleviate tumor hypoxia has recently been considered an extremely valuable target in oncology. In this review, nanotechnological strategies to elevate oxygen levels in tumor therapy in recent years are summarized, including (I) improving the hypoxic tumor microenvironment, (II) oxygen delivery to hypoxic tumors, and (III) oxygen generation in hypoxic tumors. Finally, the challenges and prospects of these nanotechnological strategies for alleviating tumor hypoxia are presented.

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Section: Nanomaterial-mediated Tumor Hypoxia Reliefmentioning

confidence: 99%

Nanotechnological strategies to increase the oxygen content of the tumor

et al. 2023

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“…HBOCs can be used as a synergist for tumor photodynamic therapy. 95 However, most organic molecular photosensitizers are characterized by hydrophobicity and poor photostability, which limit their bioavailability and efficacy of photodynamic therapy. A novel engineered erythrocyte biomimetic nanovesicle based on Hb (SPN-Hb@RBCM) can be used as an oxygen supply agent to alleviate tumor hypoxia for enhanced tumor oxygenation and the antitumor effect of near-infrared light II (NIR-II)-guided synergistic chemodynamic therapy (CDT) and photodynamic therapy (PDT).…”

Section: Application Of Hbocs 311 Application Of Hbocs In Acute Bloodmentioning

confidence: 99%

“…Due to the natural ability of Hb to transport oxygen, it has been used to modify and prepare nano- or microsized oxygen carriers. HBOCs can be used as a synergist for tumor photodynamic therapy . However, most organic molecular photosensitizers are characterized by hydrophobicity and poor photostability, which limit their bioavailability and efficacy of photodynamic therapy.…”

Section: Application Of Oxygen Carriersmentioning

confidence: 99%

Research Progress in Oxygen Carrier Design and Application

Ye,

Zheng,

Chen

et al. 2023

Mol. Pharmaceutics

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Ischemia or hypoxia can lead to pathological changes in the metabolism and function of tissues and then lead to various diseases. Timely and effective blood resuscitation or improvement of hypoxia is very important for the treatment of diseases. However, there is a need to develop stable, nontoxic, and immunologically inert oxygen carriers due to limitations such as blood shortages, different blood types, and the risk of transmitting infections. With the development of various technologies, oxygen carriers based on hemoglobin and perfluorocarbon have been widely studied in recent years. This paper reviews the development and application of hemoglobin and perfluorocarbon oxygen carriers. The design of oxygen carriers was analyzed, and their application as blood substitutes or oxygen carriers in various hypoxic diseases was discussed. Finally, the characteristics and future research of ideal oxygen carriers were prospected to provide reference for follow-up research.

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“…Although shells (lipids, SiO 2 , etc. ) , or polymer brushes , are able to be integrated onto the surface of the nanocarriers to prevent diffusion erosion of porphyrins, multiple complicated synthesis steps and extra efforts are unavoidable. This issue has been addressed by preparing porphyrin-based amphiphiles (PBAs), in which the hydrophobic porphyrins are linked with hydrophilic moieties through nondynamic covalent bonds (amide bonds, ester bonds, ether bonds, etc.)…”

Section: Introductionmentioning

confidence: 99%

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

Han,

Liu,

Peng

et al. 2023

Bioconjugate Chem.

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Porphyrins have been vastly explored and applied in many cutting-edge fields with plenty of encouraging achievements because of their excellent properties. As important derivatives of porphyrins, porphyrin-based amphiphiles (PBAs) not only maintain the advanced properties of porphyrins (catalysis, imaging, and energy transfer) but also possess self-assembly and encapsulation capability in aqueous solution. Accordingly, PBAs and their self-assembles have had important roles in diagnosing and treating tumors and inflammation lesions in vivo, but not limited to these. In this article, we introduce the research progress of PBAs, including their constitution, structure design strategies, and performances in tumor and inflammation lesion diagnosis and treatments. On that basis, the defects of synthesized PBAs during their application and the possible effective strategies to overcome the limitations are also proposed. Finally, perspectives on PBAs exploration are updated based on our knowledge. We hope this review will bring researchers from various domains insights about PBAs.

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Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat, oxygen and reactive oxygen species for suppressing hypoxic tumors

Cited by 12 publications

References 65 publications

Nanotechnological strategies to increase the oxygen content of the tumor

Nanotechnological strategies to increase the oxygen content of the tumor

Research Progress in Oxygen Carrier Design and Application

Biomedical Application of Porphyrin-Based Amphiphiles and Their Self-Assembled Nanomaterials

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