Update of Research Progress on Small Incision Lenticule Extraction (SMILE) Lenticule Reuse

Abstract

The SMILE lenticule is a complete corneal stroma that is removed from SMILE surgery. Since the increasing number of SMILE surgeries, a large number of SMILE lenticules have been produced, so the reuse and preservation of the stromal lens has become a research hotspot. Due to the rapid development of the preservation and clinical reuse of SMILE lenticules, there have been many related studies in recent years, so we updated it on this basis. We searched PubMed, Web of Science, Embase, Elsevier Science, CNKI, WANFANG Data and other databases for all articles published on the preservation and clinical reuse of SMILE lenticules, screened useful articles, selected relevant articles published in the last five years as the main body for summary, and then reached a conclusion. The existing preservation methods of SMILE lenticule include Moist chamber storage at low temperature, cryopreservation technique dehydrating agent and corneal storage medium, which have their own advantages and disadvantages. Presently, smile lenticules can be used for the treatment of corneal ulcers and perforations, corneal tissue defects, hyperopia, presbyopia and keratectasia, which have been proven to be relatively effective and safe. More research on smile lenticule reuse needs to be carried out to confirm its long-term efficacy.

Effect of Cyclotorsion Compensation in Small Incision Lenticule Extraction Surgery for the Correction of Myopic Astigmatism: A Systematic Review and Meta-Analysis

“…These benefits stem from minimally invasive incisions that better preserve anterior corneal innervation and structural integrity [ 7 , 8 ]. Consequently, SMILE has gained increasing popularity as one of the mainstream refractive surgeries [ 9 ].…”

Kerato-lenticule Extraction (KLex) surgeries – Current perspectives

“…Recent advances in clinical applications in KLex-derived lenticules include the uses in hyperopic correction, presbyopia correction, lenticule addition keratoplasty in keratoconus, and ectasia treatment for tectonic reconstruction in corneal perforation and in glaucoma drainage device implantation. [ 22 23 24 ] Current consensus on lenticule addition keratoplasty places it as an alternative procedure in management of keratoconus with the need for more studies to evaluate its long-term effects on corneal stability and induced morphological changes. In conclusion, the evolution of KLex surgeries has revolutionized the portal of corneal refractive and transplantation techniques with more to come in the recent future.…”