Update on Clostridioides difficile Infection in Older Adults

Formal Single Atom Editing of the Glycosylated Natural Product Fidaxomicin Improves Acid Stability and Retains Antibiotic Activity

“…and 0.06−0.12 μg/mL against C. perfringens. A slightly decreased activity was observed for acyl derivatives 3b-C( 11) and 3c-C (11). In comparison to the nonacylated S-OP1118 (Table S8), esterification with lipophilic alkyl carbonyl derivatives clearly lead to an increase in antibacterial potency, however, not to an extent that makes up for the loss of activity upon O-/S-exchange.…”

“…Additional data, such as the coordinate files for conformers of both epimers of the compounds 5b-C (11), 5b-C (13)…”

Clostridioides difficile infection across the lifespan: Estimation using life tables

“…1 CDI recurs in 20%-30% of CDI patients and is associated with increased risk for hospitalization, healthcare costs, and death. 2 Few databases are available to comprehensively determine risk of CDI across the age spectrum due to the fragmented system of US health insurance. Medicare data can be used to identify CDI among the permanently disabled or elderly.…”

“…1 CDI recurs in 20%–30% of CDI patients and is associated with increased risk for hospitalization, healthcare costs, and death. 2…”

How smart is the chart? Completeness of the medical record in documenting diarrhea in patients tested for Clostridioides difficile infection

“…Education of patients could empower them to participate in efforts to reduce inappropriate CDI testing. 8,9 Education of personnel to obtain information on frequency and consistency of stools could improve the accuracy of diarrhea documentation.…”