2022
DOI: 10.20944/preprints202208.0141.v1
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Update on Current Concepts in Management of Severe Hemorrhagic Shock and Optimal Individualized Fluid Therapy in Critically Ill Polytrauma Patients

Abstract: Worldwide, one of the main causes of death among young adults is multiple trauma. In these pa-tients hemorrhagic shock represents the leading cause for worsening of the clinical status and for increased morbidity and mortality. This is due to a multifactorial complex involving cellular, bi-ological, and biophysical mechanisms. The most important mechanisms affecting clinical out-come are oxidative stress, the augmentation of pro-inflammatory status, immune deficiency, dis-ruptions in the coagulation cascade, i… Show more

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