Update on Current Therapeutic Approaches in Burns

Shirani, Khan Z.; Vaughan, George M.; Mason, Arthur D.; Pruitt, Basil A.

doi:10.1097/00024382-199601000-00004

Cited by 74 publications

(37 citation statements)

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“…In wounds (especially burn wounds), necrotic tissue and the avascular eschar reduce the delivery of immune cells and systemic antibiotics, thereby enhancing the susceptibility of the wound to different bacterial infections (21)(22)(23). Topical application of an agent in an ointment or a gel provides direct contact between the antimicrobial agents and the wound pathogens.…”

Section: Nxtsc-as Inhibits Biofilm Development By Gram-positive Andmentioning

confidence: 99%

“…Biofilm-infected wounds are difficult to treat. Encasement of the bacterial pathogens within the EPS, combined with the presence of necrosis within the surrounding wound bed and decreased blood flow to the compromised areas, prevents host defense responses from reaching the infected tissues and eliminating the infection and protects the pathogens within from the effects of systemically administered antibiotics (21)(22)(23). Strategies to treat wound biofilms are multipronged, including debridement to remove the biofilm and necrotic tissue, wound dressing to control moisture in the wound bed and to protect granulating tissue from damage, and treatment of the wound bed with topical antimicrobials to prevent regrowth of the microorganisms (1,6,(24)(25)(26).…”

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confidence: 99%

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Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

Miller

Tran

Haley

et al. 2014

Antimicrob Agents Chemother

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e Loss of the skin barrier facilitates the colonization of underlying tissues with various bacteria, where they form biofilms that protect them from antibiotics and host responses. Such wounds then become chronically infected. Topical antimicrobials are a major component of chronic wound therapy, yet currently available topical antimicrobials vary in their effectiveness on biofilmforming pathogens. In this study, we evaluated the efficacy of Next Science wound gel technology (NxtSc), a novel topical agent designed to kill planktonic bacteria, penetrate biofilms, and kill the bacteria within. In vitro quantitative analysis, using strains isolated from wounds, showed that NxtSc inhibited biofilm development by Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae by inhibiting bacterial growth. The gel formulation NxtSc-G5, when applied to biofilms preformed by these pathogens, reduced the numbers of bacteria present by 7 to 8 log 10 CFU/disc or CFU/g. In vivo, NxtSc-G5 prevented biofilm formation for 72 h when applied at the time of wounding and infection and eliminated biofilm infection when applied 24 h after wounding and infection. Storage of NxtSc-G5 at room temperature for 9 months did not diminish its efficacy. These results establish that NxtSc is efficacious in vitro and in vivo in preventing infection and biofilm development by different wound pathogens when applied immediately and in eliminating biofilm infection already established by these pathogens. This novel antimicrobial agent, which is nontoxic and has a usefully long shelf life, shows promise as an effective agent for the prevention and treatment of biofilm-related infections.

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Section: Nxtsc-as Inhibits Biofilm Development By Gram-positive Andmentioning

confidence: 99%

mentioning

confidence: 99%

Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

Miller

Tran

Haley

et al. 2014

Antimicrob Agents Chemother

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“…The degree of injury depends on the duration of inhalation, the temperature, and the toxicity of the gas [16]. Injury usually occurs during a sudden explosion in a confined area.…”

Section: Discussionmentioning

confidence: 99%

Fiber-optic bronchoscopic classification of inhalation injury: prediction of acute lung injury

et al. 2004

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“…As the immediate consequence of such genesis of blisters, blister fluid is at least in the beginning with a poor protein content [66 , 67] and probably hypo or normoosmolar. Burnt tissues show hypovolemia [68,69] resulting from primary relative lack of water in the circulation. Based solely on the fact that there is no true edema with burns, one may conclude that: a) burns are not an inflammatory process at all, and b) three mentioned macroscopic signs appearing with burns are not specific for inflammation.…”

Section: Interrelationship Between Inflammation Anti-inflammatory Rementioning

confidence: 99%

Definition of Inflammation, Causes of Inflammation and Possible Anti-inflammatory Strategies

Stankov¹

2012

TOINFJ

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Current definition of inflammation by its cardinal signs is obsolete and unsuitable for guiding adequate therapeutic strategies. Furthermore, present theory of the inflammatory process regarding vascular phenomena as essential for generation of cardinal signs is invalid and unable to explain well established empirical facts, particularly the extent of the osmotic pressure and temperature variations within the inflamed tissue.

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Update on Current Therapeutic Approaches in Burns

Cited by 74 publications

References 0 publications

Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

Next Science Wound Gel Technology, a Novel Agent That Inhibits Biofilm Development by Gram-Positive and Gram-Negative Wound Pathogens

Fiber-optic bronchoscopic classification of inhalation injury: prediction of acute lung injury

Definition of Inflammation, Causes of Inflammation and Possible Anti-inflammatory Strategies

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