Update on House Dust Mite Allergen Avoidance Measures for Asthma

Zuiani, Chiara; Čustović, Adnan

doi:10.1007/s11882-020-00948-y

Cited by 33 publications

(36 citation statements)

References 65 publications

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“…It is well known that symptoms, bronchial reactivity, and pulmonary functions in HDM‐sensitized asthmatic patients correlate with the HDM allergen levels at their houses 30 . However, HDM allergen levels may vary within the same house and we could not be able to perform a standardized measurement of personal HDM exposure and indoor air quality due to the concerns of COVID‐19 transmission.…”

Section: Discussionmentioning

confidence: 97%

‘Stay at home’: Is it good or not for house dust mite sensitized children with respiratory allergies?

Yücel

Süleyman

Demirkale

et al. 2021

Pediatric Allergy Immunology

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Background Lockdown was imposed for children for 75 days in Turkey to limit the spread of COVID‐19. During this period, children have to stay indoors, which might probably increase their exposures to indoor allergens and pollutants. Besides, reduced exposures to respiratory tract infections and outdoor pollutants might be favorable outcomes of this lockdown period. We evaluated the effects of the lockdown on house dust mite (HDM)–sensitized children with respiratory allergies. Methods Three‐month clinical and medication data of 165 mild‐moderate asthmatic children with or without allergic rhinitis (AR), who were grouped according to their HDM sensitization status, were retrieved from patient records. Demographics, asthma control tests, nasal visual analog scores, and outdoor air quality monitoring data were used for assessments in comparisons with the same period in the previous year. Results Eighty‐four patients had asthma, and 81 patients had asthma with AR. Sensitization to HDM was present in 61.8% of the children. Patients experienced reduced numbers of upper respiratory tract infections (P = .008) and reduced asthma exacerbations (P < .001) compared with the same period in the previous year. Asthma control tests were significantly improved (P < .001), and cumulative inhaled corticosteroid usages were significantly reduced (P < .001). Noteworthily, nasal symptoms were significantly worsened in HDM‐sensitized asthmatics with AR (P < .001). Conclusions This study highlighted that reduction in respiratory tract infections and outdoor pollution may play roles in asthma control and prevent exacerbations despite continuous indoor allergen exposure. Besides, worsening of nasal symptoms in HDM‐sensitized asthmatics with AR implies the importance of indoor avoidance measures for AR control.

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Section: Discussionmentioning

confidence: 97%

‘Stay at home’: Is it good or not for house dust mite sensitized children with respiratory allergies?

Yücel

Süleyman

Demirkale

et al. 2021

Pediatric Allergy Immunology

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“…(44,45) Apesar da escassez de estudos de base populacional sobre a prevalência de atopia no Brasil, evidências sugerem que a sensibilização a aeroalérgenos varia de acordo com a região e o tipo de estudo. (46,47) Os estudos da eficácia de medidas de prevenção de exposição à poeira doméstica no controle da asma (48,49) ainda são controversos. Não há consenso na utilidade dessas medidas, mesmo entre diferentes diretrizes internacionais segundo um estudo realizado em 2020.…”

Section: Exposição Domiciliarunclassified

“…Não há consenso na utilidade dessas medidas, mesmo entre diferentes diretrizes internacionais segundo um estudo realizado em 2020. (49)…”

Section: Exposição Domiciliarunclassified

“…Studies examining the efficacy of measures to prevent exposure to house dust in controlling asthma 48 , 49 have yielded controversial results. There is no consensus among guidelines regarding the usefulness of such measures in accordance with a study carried out in 2020.…”

Section: Diagnostic Investigation Of Dca and Severe Asthma In Adultsmentioning

confidence: 99%

“…There is no consensus among guidelines regarding the usefulness of such measures in accordance with a study carried out in 2020. 49 …”

Section: Diagnostic Investigation Of Dca and Severe Asthma In Adultsmentioning

confidence: 99%

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2021 Brazilian Thoracic Association recommendations for the management of severe asthma

et al. 2021

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Advances in the understanding that severe asthma is a complex and heterogeneous disease and in the knowledge of the pathophysiology of asthma, with the identification of different phenotypes and endotypes, have allowed new approaches for the diagnosis and characterization of the disease and have resulted in relevant changes in pharmacological management. In this context, the definition of severe asthma has been established, being differentiated from difficult-to-control asthma. These recommendations address this topic and review advances in phenotyping, use of biomarkers, and new treatments for severe asthma. Emphasis is given to topics regarding personalized management of the patient and selection of biologicals, as well as the importance of evaluating the response to treatment. These recommendations apply to adults and children with severe asthma and are targeted at physicians involved in asthma treatment. A panel of 17 Brazilian pulmonologists was invited to review recent evidence on the diagnosis and management of severe asthma, adapting it to the Brazilian reality. Each of the experts was responsible for reviewing a topic or question relevant to the topic. In a second phase, four experts discussed and structured the texts produced, and, in the last phase, all experts reviewed and approved the present manuscript and its recommendations.

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Environmental risk factors for respiratory infection and wheeze in young children: A multicentre birth cohort study

Ruffles,

Inglis,

Memon

et al. 2023

Pediatric Pulmonology

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IntroductionRespiratory infections and wheeze have a considerable impact on the health of young children and consume significant healthcare resources. We aimed to evaluate the effect of environmental factors on respiratory infections and symptoms in early childhood.MethodsEnvironmental risk factors including: daycare attendance; breastfeeding; siblings; damp within the home; environmental tobacco smoke (ETS); child's bedroom flooring; animal exposure; road traffic density around child's home; and solid fuel pollution within home were assessed in children recruited to the GO‐CHILD multicentre prospective birth cohort study. Follow‐up information on respiratory infections (bronchiolitis, pneumonia, otitis media and cold or flu), wheeze and cough symptoms, healthcare utilisation and medication prescription was collected by postal questionnaires at 12 and 24 months. Log binomial and ordered logistic regression models were fitted to the data.ResultsFollow‐up was obtained on 1344 children. Daycare was associated with increased odds of pneumonia (odds ratio [OR] = 2.39, 95% confidence interval [CI]: 1.04−5.49), bronchiolitis (OR = 1.40, 1.02−1.90), otitis media (OR = 1.68, 1.32−2.14) and emergency department attendance for wheeze (RR = 1.81, 1.17−2.80). Breastfeeding beyond 6 months was associated with a reduced odds of bronchiolitis (OR = 0.55, 0.39−0.77) and otitis media (OR = 0.75, 0.59−0.99). Siblings at home was associated with an increased odds of bronchiolitis (OR = 1.65, 1.18−2.32) and risk of reliever inhaler prescription (RR = 1.37, 1.02−1.85). Visible damp was associated with an increased odds of wheeze (OR = 1.85, 1.11−3.19), and risk of reliever inhaler (RR = 1.73, 1.04−2.89) and inhaled corticosteroid prescription (RR = 2.61, 1.03−6.59). ETS exposure was associated with an increased odds of primary care attendance for cough or wheeze (OR = 1.52, 1.11−2.08). Dense traffic around the child's home was associated with an increased odds of bronchiolitis (OR = 1.32, 1.08−2.29).ConclusionEnvironmental factors likely influence the wide variation in infection frequency and symptoms observed in early childhood. Larger population studies are necessary to further inform and guide public health policy to decrease the burden of respiratory infections and wheeze in young children.

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Update on House Dust Mite Allergen Avoidance Measures for Asthma

Cited by 33 publications

References 65 publications

‘Stay at home’: Is it good or not for house dust mite sensitized children with respiratory allergies?

‘Stay at home’: Is it good or not for house dust mite sensitized children with respiratory allergies?

2021 Brazilian Thoracic Association recommendations for the management of severe asthma

Environmental risk factors for respiratory infection and wheeze in young children: A multicentre birth cohort study

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