Update on liver fluke in sheep

Williams, Diana

doi:10.1136/inp.m2398

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Adult flukes, which settle in the bile ducts, may cause mechanical obstruction of the bile ducts [ 17 ]. As the adults have microscopic spines on their tegument, the movements of the flukes harm the inside of the bile ducts resulting in thickened bile ducts and cholangitis with hyperplasia of the epithelium [ 19 ]. The juvenile and the mature Fasciola -stages feed by producing enzymes, particularly proteases, which degrade blood and the liver parenchyma [ 19 ].…”

Section: Fasciolidae With Emphasis On the Common Liver Flukementioning

confidence: 99%

Chronic Wasting Due to Liver and Rumen Flukes in Sheep

Kahl

Samson‐Himmelstjerna

Krücken

et al. 2021

Animals

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Grazing sheep and goats are constantly exposed to helminth infections in many parts of the world, including several trematode species that causes a range of clinical diseases. The clinical picture of flukes is dependent upon the organs in which they develop and the tissues they damage within the respective organs. Accordingly, infections with the common liver fluke Fasciola hepatica, which, as juvenile worm migrates through the liver parenchyma for several weeks, may be associated with hepatic disorders such as impairment of carbohydrate, protein and fat metabolism, followed by chronic wasting. In contrast, the lancet fluke Dicrocoelium dendriticum, which does not exhibit tissue migration and thus does not lead to major tissue damage and bleeding, also does not lead to significant clinical symptoms. Rumen flukes such as Cotylophoron daubneyi cause catarrhal inflammation during their migration through the intestinal and abomasal epithelium during its juvenile stages. Depending on the infection intensity this may result in a range of clinical symptoms including diarrhoea, inappetence or emaciation. In this review, we aim to provide an update on the current knowledge on flukes particularly concerning the clinical relevance of the most important fluke species in sheep.

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Section: Fasciolidae With Emphasis On the Common Liver Flukementioning

confidence: 99%

Chronic Wasting Due to Liver and Rumen Flukes in Sheep

Kahl

Samson‐Himmelstjerna

Krücken

et al. 2021

Animals

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“…Belcher Pharmaceuticals received FDA approval with orphan drug designation for Ablysinol (dehydrated alcohol) for adult heart disease (2). Such designation precludes medical marketing by others until 2025 and recently resulted in shortage and almost 8‐fold price increase (3).…”

mentioning

confidence: 99%

Heightened Central Line‐associated Blood Stream Infection Risk During a Pandemic

Mezoff

Galloway

Cole

2020

J. pediatr. gastroenterol. nutr.

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After 1 month, pruritus disappeared and sBA normalized (4.6 mmol/L). Follow-up at 3 and 8 months confirmed the absence of pruritus and cholestasis (sBA: 1.9 and 5 mmol/L). Serum liver tests, alpha-fetoprotein level, and liver elastography value (Supersonic Shear Imaging: 6 kPa) were normal. This report shows that in our PFIC2 patient GPB is as efficient as PBA to improve pruritus and cholestasis and allows good oral tolerance and therapeutic adherence.

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“…These were climate change, economic factors, barriers to changing disease prevention strategies and disease risk factors. In recent years, there has been an increased burden of liver fluke infection with significant effects on livestock productivity 26 27. This was particularly evident in the winter of 2012–2013, in which farmers observed a high incidence of clinical disease caused by F hepatica in their sheep 28.…”

Section: Discussionmentioning

confidence: 99%

“…Triclabendazole has been used extensively in highly endemic areas of Britain, and resistance is now widespread 44. Raising farmer awareness of resistance and providing alternative control options, which are often less easy to implement than blanket drug treatment at predefined times, are critical to maintaining the efficacy of the small number of effective flukicides currently on the market 27. The farmers involved in this study said the information provided from the 2013 trial empowered them to make informed choices when changing their control programmes to minimise the risk of losses.…”

Section: Discussionmentioning

confidence: 99%

Providing information about triclabendazole resistance status influences farmers to change liver fluke control practices

et al. 2020

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BackgroundReports of disease and production losses associated with Fasciola hepatica, the common liver fluke, have increased in recent years. Resistance to triclabendazole, one of the principal veterinary medicines used to prevent losses, has been reported and is now considered widespread in fluke endemic regions of the UK.MethodsThirteen farmers participated in a trial in 2013 and the triclabendazole resistance status was obtained for each farm. Based on these results, a knowledge exchange programme on fluke control was delivered to nearly 100 farmers in the region. In this follow-up study, 11 farmers involved in the original trial, participated in semistructured in-depth qualitative interviews in July 2017.ResultsOverall, participants identified benefits from participating in the 2013 trial, gaining information about triclabendazole resistance on their farms and knowledge about fluke control. The information on their farm’s resistance status was a driver for changing their liver fluke control programmes. Factors such as habitual and repetitive behaviours, grazing restrictions due to agri-environmental schemes, economic pressures and climate change were identified that could impede or prevent the adoption of new control strategies.ConclusionsThe study highlights the significance of resistance to triclabendazole and the impact of knowledge exchange programmes in changing liver fluke control practices.

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Update on liver fluke in sheep

Cited by 4 publications

References 25 publications

Chronic Wasting Due to Liver and Rumen Flukes in Sheep

Chronic Wasting Due to Liver and Rumen Flukes in Sheep

Heightened Central Line‐associated Blood Stream Infection Risk During a Pandemic

Providing information about triclabendazole resistance status influences farmers to change liver fluke control practices

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