Update on Long-Acting Anticholinergics in Children and Adolescents With Difficult and Severe Asthma

Santamaria, Francesca; Ziello, Carla; Lorello, Paola; Bouchè, Cristina; Borrelli, Melissa

doi:10.3389/fped.2022.896865

Cited by 4 publications

(2 citation statements)

References 53 publications

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“… The recommended option is medium-dose ICS/LABA either MART of ICS/Formoterol or daily of ICS/non-formoterol LABA inhaler with SABA as a reliever[ 393 394 395 396 397 398 399 ] Tiotropium or LTRA may be added to this combination if control is not achieved[ 408 409 410 ] Whenever there is difficulty controlling asthma at Step 4, it is strongly recommended to refer the child to a physician specialized in asthma for further evaluation. …”

Section: Section 9: Asthma In Childrenmentioning

confidence: 99%

The Saudi initiative for asthma – 2024 update: Guidelines for the diagnosis and management of asthma in adults and children

Al-Moamary,

Alhaider,

Allehebi

et al. 2023

Annals of Thoracic Medicine

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The Saudi Initiative for Asthma 2024 (SINA-2024) is the sixth version of asthma guidelines for the diagnosis and management of asthma for adults and children that was developed by the SINA group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up-to-date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA Panel approach is mainly based on the assessment of symptom control and risk for both adults and children. The approach to asthma management is aligned for age groups: adults, adolescents, children aged 5–12 years, and children aged <5 years. SINA guidelines have focused more on personalized approaches reflecting a better understanding of disease heterogeneity with the integration of recommendations related to biologic agents, evidence-based updates on treatment, and the role of immunotherapy in management. The medication appendix has also been updated with the addition of recent evidence, new indications for existing medication, and new medications. The guidelines are constructed based on the available evidence, local literature, and the current situation at national and regional levels. There is also an emphasis on patient–doctor partnership in the management that also includes a self-management plan.

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Section: Section 9: Asthma In Childrenmentioning

confidence: 99%

The Saudi initiative for asthma – 2024 update: Guidelines for the diagnosis and management of asthma in adults and children

Al-Moamary,

Alhaider,

Allehebi

et al. 2023

Annals of Thoracic Medicine

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show abstract

“…Tiotropium bromide is the only LAMA licensed for long-term treatment of asthma in patients aged ≥6 years who continue to have symptoms despite controller medication administration [129]. As with tiotropium, glycopyrronium is an anticholinergic with higher selectivity for M3 receptors than for M2 receptors and dissociates more slowly from the M3 receptors than from the M2 receptors [130].…”

Section: Recommendationmentioning

confidence: 99%

Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group

Fainardi,

Caffarelli,

Deolmi

et al. 2023

JCM

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Asthma is the most frequent chronic disease of childhood, affecting up to 20% of children worldwide. The main guidelines on asthma maintenance therapy in pediatrics suggest different approaches and describe different stages of asthma to determine the most appropriate treatment. This project aims to summarize the most recent evidence regarding maintenance therapy for asthma in children and adolescents. A multidisciplinary panel of experts was asked clinical questions regarding the treatment of children and adolescents with asthma. Overall, 10 clinical questions were addressed, and the search strategy included accessing electronic databases and a manual search of gray literature published in the last 25 years. After data extraction and narrative synthesis of results, recommendations were developed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology. Results showed that the choice of medication depends on the severity of the child’s asthma, phenotype, age, preference, and individual factors. In addition to medications, the identification of comorbidities and modifiable factors is crucial to obtaining good control. Asthma in children is heterogeneous, and its evolution varies over time. Since most recommendations for asthma management in childhood are extrapolated from clinical studies performed in adults, more clinical trials specifically designed for young children should be conducted.

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Triple inhaled therapy in asthma: Beliefs, behaviours and doubts

Bagnasco,

Ansotegui,

Baiardini

et al. 2024

Pulmonary Pharmacology & Therapeutics

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Update on Long-Acting Anticholinergics in Children and Adolescents With Difficult and Severe Asthma

Cited by 4 publications

References 53 publications

The Saudi initiative for asthma – 2024 update: Guidelines for the diagnosis and management of asthma in adults and children

The Saudi initiative for asthma – 2024 update: Guidelines for the diagnosis and management of asthma in adults and children

Maintenance Therapy for Children and Adolescents with Asthma: Guidelines and Recommendations from the Emilia-Romagna Asthma (ERA) Study Group

Triple inhaled therapy in asthma: Beliefs, behaviours and doubts

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