Update on mosquito bite reaction: Itch and hypersensitivity, pathophysiology, prevention, and treatment

Does, Ashley Vander; Labib, Angelina; Yosipovitch, Gil

doi:10.3389/fimmu.2022.1024559

Cited by 20 publications

(11 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was shared frequently that young children suffer bouts of malaria more often (have obvious and sometimes severe symptoms) than adults. Similarly, this study and others found parents and caregivers were more cautious about babies and toddlers being bitten by mosquitoes because they have a stronger reaction to bites and the potential allergy reaction from the bites [ 41 – 43 ]. The study revealed that bed nets are mostly used for small children because their reaction to bites is more severe than for adults.…”

Section: Discussionmentioning

confidence: 53%

How using light touch immersion research revealed important insights into the lack of progress in malaria elimination in Eastern Indonesia

Jupp,

Ayuandini,

Tobing

et al. 2024

Malar J

View full text Add to dashboard Cite

Background By 2022, the Government of Indonesia had successfully eliminated malaria in 389 out of 514 districts but continues to face a challenge in Eastern Indonesia where 95% of the total 2021 malaria cases were reported from Papua, West Papua and Nusa Tenggara Timur provinces. There is an increased recognition that malaria elimination will require a better understanding of the human behavioural factors hindering malaria prevention and treatment, informed by local context and local practice. Methods This research used a light-touch immersion research approach. Field researchers lived in communities over several days to gather data through informal conversations, group-based discussions using visual tools, participant observation and direct experience. The study was conducted in four high malaria endemic areas in Papua, West Papua, and Sumba Islands in Nusa Tenggara Timur. Results The research highlights how people’s perception of malaria has changed since the introduction of effective treatment which, in turn, has contributed to a casual attitude towards early testing and adherence to malaria treatment. It also confirms that people rarely accept there is a link between mosquitoes and malaria based on their experience but nevertheless take precautions against the annoyance of mosquitoes. There is widespread recognition that babies and small children, elderly and incomers are more likely to be seriously affected by malaria and separately, more troubled by mosquitoes than indigenous adult populations. This is primarily explained by acclimatization and strong immune systems among the latter. Conclusions Using immersion research enabled behaviour research within a naturalistic setting, which in turn enabled experiential-led analysis of findings and revealed previously unrecognized insights into attitudes towards malaria in Eastern Indonesia. The research provides explanations of people’s lack of motivation to consistently use bed nets, seek early diagnosis or complete courses of treatment. The felt concern for the wellbeing of vulnerable populations highlighted during light touch immersion provides an entry point for future social behaviour change communication interventions. Rather than trying to explain transmission to people who deny this connection, the research concludes that it may be better to focus separately on the two problems of malaria and mosquitoes (especially for vulnerable groups) thereby resonating with local people’s own experience and felt concerns.

show abstract

Section: Discussionmentioning

confidence: 53%

How using light touch immersion research revealed important insights into the lack of progress in malaria elimination in Eastern Indonesia

Jupp,

Ayuandini,

Tobing

et al. 2024

Malar J

View full text Add to dashboard Cite

show abstract

“…His research team has been focusing on neuroimmune mechanisms and clinical treatment in chronic pruritus. 32 This was followed by Sonja Staender (84 papers) and Jacek C Szepietowski (50 papers). Most of these prolific authors were from highly productive countries or institutions and showed strong collaborative relationships.…”

Section: Resultsmentioning

confidence: 99%

“…The most published author in this field was Gil Yosipovitch from the Itch Research Center at the University of Miami, USA, with 88 publications and 3169 citations. His research team has been focusing on neuroimmune mechanisms and clinical treatment in chronic pruritus 32 . This was followed by Sonja Staender (84 papers) and Jacek C Szepietowski (50 papers).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis

Li,

Wang,

Yin

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

AimsItch, a common uncomfortable sensory experience, occurs frequently in inflammatory or allergic disorders. In recent years, with the discovery of itch‐specific pathways in the peripheral and central nervous system, the association between immunology and neural pathways has gradually emerged as the main mechanism of itch. Although many studies have been conducted on itch, no bibliometric analysis study focusing on this topic has been conducted. This study aimed to explore the research hotspots and trends in the itch field from a bibliometric perspective.MethodsPublications relevant to itch, published from 2003 to 2022, were retrieved from the Science Citation Index‐Expanded of Web of Science Core Collection. Publications were critically reviewed and analyzed with CiteSpace software, Vosviewer, and the bibliometric online analysis platform. Visual maps were conducted in terms of annual production, collaborating countries or institutions, productive authors, core journals, co‐cited references, and keyword bursts.Results2395 articles on itch that met our criteria were identified and the quantity of publications has been increasing rapidly since 2012. The USA was the most influential country. University Hospital Münster was the institution with the most publications. Gil Yosipovitch was the most prolific author. Atopic dermatitis (AD), intradermal serotonin, chronic pruritus, mechanical itch, gastrin‐releasing peptide, substance p, interleukin‐31 receptor, histamine‐induced itch, bile acid, scratching behavior, and h‐4 receptor were the top 11 clusters in co‐citation cluster analysis. Keyword burst analysis suggested that treatment, inflammation, and AD are current research hotspots.ConclusionGlobal publications on itch research have increased steadily and rapidly over the past 20 years. Inflammation and AD are current research hotspots. The neuroimmunological and neuroinflammatory mechanisms of itch, as well as clinical assessment methods and therapeutic targets, will be novel research directions in the future. This study provides guidance for further itch research.

show abstract

“… 47 In agreement with this, off-label use of oral sgAHs in adults and in children has been shown to decrease whealing and accompanying pruritus in placebo-controlled trials. 48 Rupatadine 10 mg is effective in reducing itching and wheals associated with mosquito bite allergy as evaluated in a double-blind, placebo-controlled study. 49 …”

Section: Reviewmentioning

confidence: 99%

How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review

Izquierdo,

Casas,

Cabrera

et al. 2024

DIC

View full text Add to dashboard Cite

The off-label use of second-generation antihistamines, used outside of the formal indications authorized by regulatory authorities, in different age groups, doses or in special populations, is very common for many allergic, autoimmune and dermatological diseases. The off-label use of rupatadine (a second-generation antihistamine with PAF antagonist activity) in these conditions is reviewed here, including in combination with immunotherapy in the treatment of food allergy or allergic rhinitis, at high doses in chronic urticaria, and with prescriptions of less common but challenging conditions such as skin pruritus or mast cell activation disorders like mastocytosis. Rupatadine use is reviewed herein to confirm if its off-label management is supported by well-designed clinical trials or by published real-world cases. This review will contribute to increasing compliance and achieving better results in clinical practice. Off-label use of rupatadine should be left to the discretion of the prescribing healthcare professional after careful clinical evaluation.

show abstract

Update on mosquito bite reaction: Itch and hypersensitivity, pathophysiology, prevention, and treatment

Cited by 20 publications

References 89 publications

How using light touch immersion research revealed important insights into the lack of progress in malaria elimination in Eastern Indonesia

How using light touch immersion research revealed important insights into the lack of progress in malaria elimination in Eastern Indonesia

Emerging trends and hotspots of the itch research: A bibliometric and visualized analysis

How to handle off-label prescriptions of rupatadine, a second-generation antihistamine and PAF antagonist: a review

Contact Info

Product

Resources

About