Update on multiparametric MRI of urinary bladder cancer

Pol, Christian B. van der; Chung, Andrew D.; Lim, Christopher; Gandhi, Niket; Tu, Wendy; McInnes, Matthew D. F.; Schieda, Nicola

doi:10.1002/jmri.26294

Cited by 57 publications

(34 citation statements)

References 103 publications

(229 reference statements)

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“…Our study revealed mp-MRI diagnostic accuracy of 98.1% in differentiating organ-confined from non-organconfined tumors. This was better than van der Pol et al [1] who reported diagnostic accuracy of 81 to 83% and Afifi et al [15] who reported diagnostic accuracy of 88%.…”

Section: A B C D E Fmentioning

confidence: 54%

“…Preoperative staging of urinary bladder carcinomas using TNM system is crucial in the management of bladder cancer which is determined mainly by stage and grade of tumor at diagnosis [1,12].…”

Section: Discussionmentioning

confidence: 99%

“…It is expected that utilization of mp-MRI for bladder cancer local T staging will increase as awareness of its accuracy in the urology community improves. Several recent meta-analyses assessing the topic of local staging of bladder cancer with mp-MRI confirm an increase in the potential benefits of performing mp-MRI [1].…”

Section: A B C D E Fmentioning

confidence: 94%

“…Clinical management of urinary bladder cancer is determined primarily on the basis of distinguishing superficial tumors (stage T1 or lower) from invasive ones (stage T2 or higher) because the treatment options differ considerably [1]. Superficial tumors are treated with transurethral resection (TUR) with or without adjuvant intravesical chemotherapy or photodynamic therapy [2], whereas invasive tumors are treated with radical cystectomy, radiation therapy, chemotherapy, or a combination [3].…”

Section: Introductionmentioning

confidence: 99%

“…Multiple studies have proved that 3-T MRI shows a better specificity and sensitivity than 1.5-T MRI when used to diagnose and stage bladder cancer. Therefore, the guidelines recommend the use of multi-parametric 3-T MRI to improve the diagnostic accuracy for determining bladder cancer T stage [1].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic performance of 3-tesla multiparametric MRI for assessment of the bladder cancer T stage and histologic grade

Badawy

Farg

Gadelhak

et al. 2020

Egypt J Radiol Nucl Med

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Background Preoperative staging of urinary bladder carcinomas using TNM system is crucial in the management of bladder cancer which is determined mainly by stage and grade of tumor at diagnosis. We aim to evaluate the diagnostic accuracy of multiparametric MRI (mp-MRI) for assessment of the bladder cancer T stage and histologic grade. Results The overall T2-WI diagnostic accuracy for the T stage was 72.3%, increased to be 87.1% for contrast-enhanced images, and 92.6% for DWI, reaching the maximum accuracy 94.5% using the combined multi-parametric MRI technique. Diagnostic accuracies of mp-MRI in differentiating superficial from muscle-invasive (91%) and organ-confined from non-organ confined tumors (92%) were superior to DW-MRI (89% and 87%), DCE-MRI (84% and 83%), and T2W-MRI (74% and 71%), respectively. The agreement between MRI findings and histopathological staging was greater in mp-MRI (k = 0.91; excellent agreement) than in DW-MRI (k = 0.77; moderate agreement), DCE-MRI (k = 0.76; substantial agreement), and T2W-MRI (k = 0.53; fair agreement). Conclusion Mp-MRI provides useful information for evaluating the local T stages of bladder cancer and can predict the histological grades of urinary bladder cancers with high diagnostic accuracy.

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Section: A B C D E Fmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: A B C D E Fmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic performance of 3-tesla multiparametric MRI for assessment of the bladder cancer T stage and histologic grade

Badawy

Farg

Gadelhak

et al. 2020

Egypt J Radiol Nucl Med

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Engineering of Kidney‐Targeting Fluorophores with Tunable Emission from NIR‐I to NIR‐II for Early Diagnosis of Kidney Disease

Jiang,

Wang,

et al. 2024

Adv Healthcare Materials

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The development of rapidly distributed and retained probes within the kidneys is important for accurately diagnosing kidney diseases. Although molecular imaging shows the potential for non‐intrusively interrogating kidney disease‐related biomarkers, the limited kidney contrast of many fluorophores, owing to their relatively low distribution in the kidney, hinders their effectiveness for kidney disease detection. Herein, for the first time, an amino‐functionalization strategy is proposed to construct a library of kidney‐targeting fluorophores NHcy with tunable emissions from NIR‐I to NIR‐II. Among these, NHcy‐8 is the first small‐molecule NIR‐II dye without a renal clearance moiety, designed specifically for kidney‐targeting imaging. Building on this class of NIR‐II fluorophore, the first NIR‐II small‐molecule kidney‐targeting pH probe NIR‐II‐pH is developed, which exhibits a desirable kidney distribution after intravenous injection and is fluorescent only after activation by acidosis. NIR‐II in vivo fluorescence/photoacoustic imaging of kidney disease models induced by cisplatin and renal I/R injury using NIR‐II‐pH reveals increasingly severe metabolic acidosis as the disease progressed, enabling sensitive detection of the onset of acidosis 36 h (cisplatin group) earlier than clinical methods. Thus, this study introduces a practical NIR‐II kidney‐targeting probe and provides a useful molecular blueprint for guiding kidney‐targeting NIR‐II fluorophores as diagnostic aids for kidney diseases.

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A Renal‐Clearable Macromolecular Reporter for Near‐Infrared Fluorescence Imaging of Bladder Cancer

Huang

Jiang

et al. 2020

Angewandte Chemie

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Bladder cancer (BC) is a prevalent disease with high morbidity and mortality; however, in vivo optical imaging of BC remains challenging because of the lack of cancer‐specific optical agents with high renal clearance. Herein, a macromolecular reporter (CyP1) was synthesized for real‐time near‐infrared fluorescence (NIRF) imaging and urinalysis of BC in living mice. Because of the high renal clearance (ca. 94 % of the injection dosage at 24 h post‐injection) and its cancer biomarker (APN=aminopeptidase N) specificity, CyP1 can be efficiently transported to the bladder and specially turn on its NIRF signal to report the detection of BC in living mice. Moreover, CyP1 can be used for optical urinalysis, permitting the ex vivo tracking of tumor progression for therapeutic evaluation and easy translation of CyP2 as an in vitro diagnostic assay. This study not only provides new opportunities for non‐invasive diagnosis of BC, but also reveals useful guidelines for the development of molecular reporters for the detection of bladder diseases.

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Update on multiparametric MRI of urinary bladder cancer

Abstract: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:882-896.

Cited by 57 publications

References 103 publications

Diagnostic performance of 3-tesla multiparametric MRI for assessment of the bladder cancer T stage and histologic grade

Diagnostic performance of 3-tesla multiparametric MRI for assessment of the bladder cancer T stage and histologic grade

Engineering of Kidney‐Targeting Fluorophores with Tunable Emission from NIR‐I to NIR‐II for Early Diagnosis of Kidney Disease

A Renal‐Clearable Macromolecular Reporter for Near‐Infrared Fluorescence Imaging of Bladder Cancer

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