Update on Peripheral Nervous System Tumors: Lesions with Epithelioid and Melanotic Features

Prieto-Granada, Carlos

doi:10.1016/j.hpr.2022.300614

Cited by 2 publications

(1 citation statement)

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“…In MPNST, significant differential activation in circuits related to the protective effect triggered by the TME on the FceRI signaling pathway, previously described, as well as a putative melanotic feature and neuron response to the hormones prolactin and oxytocin, was found. Different receptors activate Phospholipase C, triggering, in one case, melamin synthesis, previously observed in malignant melanotic nerve sheath tumors [100], and, in the oxytocin pathway, the release of calcium stored in intracellular pools into the cytoplasm via RYR1, leading to the secretion of oxytocin. In both cases, the prolactin and oxytocin pathways activate the MAPK signaling pathway to enhance cell proliferation through cyclin D1.…”

Section: Specific Circuits In Sarcoma Subtypesmentioning

confidence: 87%

Functional Profiling of Soft Tissue Sarcoma Using Mechanistic Models

Payá-Milans,

Peña-Chilet,

Loucera

et al. 2023

IJMS

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Soft tissue sarcoma is an umbrella term for a group of rare cancers that are difficult to treat. In addition to surgery, neoadjuvant chemotherapy has shown the potential to downstage tumors and prevent micrometastases. However, finding effective therapeutic targets remains a research challenge. Here, a previously developed computational approach called mechanistic models of signaling pathways has been employed to unravel the impact of observed changes at the gene expression level on the ultimate functional behavior of cells. In the context of such a mechanistic model, RNA-Seq counts sourced from the Recount3 resource, from The Cancer Genome Atlas (TCGA) Sarcoma project, and non-diseased sarcomagenic tissues from the Genotype-Tissue Expression (GTEx) project were utilized to investigate signal transduction activity through signaling pathways. This approach provides a precise view of the relationship between sarcoma patient survival and the signaling landscape in tumors and their environment. Despite the distinct regulatory alterations observed in each sarcoma subtype, this study identified 13 signaling circuits, or elementary sub-pathways triggering specific cell functions, present across all subtypes, belonging to eight signaling pathways, which served as predictors for patient survival. Additionally, nine signaling circuits from five signaling pathways that highlighted the modifications tumor samples underwent in comparison to normal tissues were found. These results describe the protective role of the immune system, suggesting an anti-tumorigenic effect in the tumor microenvironment, in the process of tumor cell detachment and migration, or the dysregulation of ion homeostasis. Also, the analysis of signaling circuit intermediary proteins suggests multiple strategies for therapy.

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Section: Specific Circuits In Sarcoma Subtypesmentioning

confidence: 87%