Update on retinal vessel structure measurement with spectral-domain optical coherence tomography

Zhu, Tie Pei; Tong, Yu Hua; Zhan, Hai Jing; Ma, Jin

doi:10.1016/j.mvr.2014.06.007

Cited by 29 publications

(28 citation statements)

References 27 publications

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“…Previous studies involving direct measurements of vessel diameters using the Image J software (National Institutes of Health, Bethesda, MD, USA) reported high repeatability and reproducibility. 11,14 In our study, the intra-and interobserver ICCs for OCT vessel diameter measurements were also highly repeatable and reproducible, especially in measuring the luminal diameter, the ICCs were 40.90. Other parameter measurements also had relatively good ICCs of 40.80.…”

Section: Discussionsupporting

confidence: 62%

“…Different sizes of the inner and outer walls were also reported in previous studies. 11,14 The inner walls were thicker compared with the outer walls, with 75% in arteries (30/40, data not shown) and 82.5% in veins (33/40, data not shown). In general, the inner wall was more intense and thicker compared with the outer wall because of decreases in light intensity at increasing distances.…”

Section: Discussionmentioning

confidence: 90%

“…Muraoka et al 11 used zone A and reported that the OCT beam was projected perpendicular to the retinal surface in a circular scan, with vertical sections of all major retinal vessels reliably obtained with a single scan. However, Zhu et al 14 reported that SD-OCT measurements of vessels in zone B were more accurate compared with in zone A. Currently, discriminating the junction of the wall and lumen, or wall Abbreviations: CI, confidence interval; ICC, intraclass correlation coefficient; Sw, within-subject standard deviation.…”

Section: Discussionmentioning

confidence: 99%

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Retinal vessel structure measurement using spectral-domain optical coherence tomography

Rim

Choi

Kim

et al. 2015

Eye

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Purpose To assess the reliability and validity of spectral-domain optical coherence tomography (SD-OCT) measurements of retinal vessel lumen diameters and wall thicknesses. Methods SD-OCT was used to characterize the circular region around the optic disc of 40 eyes (20 subjects). The inner and outer sides (vitreal and choroidal sides) of the vessel wall and the luminal diameter were measured using intensity graphs. Results Mean arterial and venous luminal diameters were 95.1 ± 16.1 and 132.6 ± 17.8 μm, respectively. The wall thicknesses of inner and outer sides of the artery were 23.9 ± 4.9 and 21.2 ± 3.5 μm, respectively. The wall thicknesses of the inner and outer sides of the vein were 20.7 ± 4.2 and 16.3 ± 4.3 μm, respectively. There were significant differences between the inner and outer wall thicknesses in both the artery and vein (Po0.01). Intra-and interobserver intraclass correlation coefficients (ICCs) for lumen measurements were 40.95, and for wall thicknesses were 40.85, except for the outer wall thickness measurements. The mean value of outer and inner wall thicknesses showed good reproducibility, with ICCs of 40.85. Conclusion Intensity graph-assisted measurements using SD-OCT provided more objective information in finding boundaries of vessels. Luminal diameters and wall thicknesses obtained with OCT showed good overall reproducibility, with inner wall thicknesses being thicker, and with better reproducibility compared with outer wall thicknesses, where ICC values were the lowest among the inner wall thicknesses, mean thicknesses of inner and outer walls, and luminal diameters. When using SD-OCT measurements, caution is therefore advised when using only the outer wall as representative of the wall thicknesses.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Retinal vessel structure measurement using spectral-domain optical coherence tomography

Rim

Choi

Kim

et al. 2015

Eye

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“…There is a single report of a decrease in relative blood flow to the optic nerve head in MS eyes, measured using OCT angiography [25]. However, this technique is not yet widely available in the clinical setting, compared to quantitative static retinal blood vessel metrics which can be extracted from OCT scans that are acquired using currently available clinical instrumentation [26][27][28]. We sought to investigate quantitative retinal blood vessel metrics as a marker of MS using a cross sectional study of retinal blood vessel diameters in individuals with and without MS, and with and without a history of ON.…”

Section: Introductionmentioning

confidence: 99%

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Bhaduri

Nolan

Shelton

et al. 2016

Biomed. Opt. Express

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Although retinal vasculitis is common in multiple sclerosis (MS), it is not known if MS is associated with quantitative abnormalities in retinal blood vessels (BVs). Optical coherence tomography (OCT) is suitable for examining the integrity of the anterior visual pathways in MS.In this paper we have compared the size and number of retinal blood vessels in patients with MS, with and without a history of optic neuritis (ON), and control subjects from the cross-sectional retinal images from OCT. Blood vessel diameter (BVD), blood vessel number (BVN), and retinal nerve fiber layer thickness (RNFL T ) were extracted from OCT images collected from around the optic nerves of 129 eyes (24 control, 24 MS + ON, 81 MS-ON) of 71 subjects. Associations between blood vessel metrics, MS diagnosis, MS disability, ON, and RNFL T were evaluated using generalized estimating equation (GEE) models. MS eyes had a lower total BVD and BVN than control eyes. The effect was more pronounced with increased MS disability, and persisted in multivariate models adjusting for RNFL T and ON history. Twenty-nine percent (29%) of MS subjects had fewer retinal blood vessels than all control subjects. MS diagnosis, disability, and ON history were not associated with average blood vessel size. The relationship between MS and lower total BVD/BVN is not accounted for by RNFL T or ON. Further study is needed to determine the relationship between OCT blood vessel metrics and qualitative retinal blood vessel abnormalities in MS. Huang, "Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis," Br. J. Ophthalmol. 98(10),

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“…However, we should note that the concept of ERI does not mean a complete restoration of high-resolution images without additional image information but image enhancement. We believe that the ERI method is useful as a type of display format in the analysis of fine structures in OCT images such as hyper-reflective foci [31,32,33,37], the retinal nerve fiber layer near the fovea [38,39], intricately affected photoreceptor layers [40,41], and vessels [42,43]. Further, MBP as well as IBP suffer from the drawback of noise enhancement.…”

Section: Discussionmentioning

confidence: 99%

Enhanced-Resolution Optical Coherence Tomography Imaging

Uji

Murakami²,

Shigeta³

et al. 2016

Ophthalmologica

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Purpose: The effect of the enhanced-resolution imaging (ERI) technique on optical coherence tomography (OCT) images was evaluated. Methods: A total of 5 healthy subjects and 20 patients diagnosed with various eye diseases were recruited into the study. ERI, a novel image processing technique, was accomplished by using super-resolution technology, and was assessed by objectively and subjectively comparing the image quality among three different image groups: images enlarged without bicubic interpolation (NONE), with bicubic interpolation (IP), and with ERI. Results: ERI showed a higher ratio of the detailed variance to the background variance than NONE, whereas no significant difference was detected between NONE and IP. The mean opinion score of 5 experienced retinal specialists for ERI was significantly higher than that for IP. Conclusions: ERI generated a sharper image and clearly visualized small objects. Additionally, it is effective in enhancing OCT image quality.

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Update on retinal vessel structure measurement with spectral-domain optical coherence tomography

Cited by 29 publications

References 27 publications

Retinal vessel structure measurement using spectral-domain optical coherence tomography

Retinal vessel structure measurement using spectral-domain optical coherence tomography

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Enhanced-Resolution Optical Coherence Tomography Imaging

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