Update on Testosterone Replacement Therapy in Hypogonadal Men

Leung, Kevin M.Y.B.; Alrabeeah, Khalid; Carrier, Serge

doi:10.1007/s11934-015-0523-9

Cited by 6 publications

(5 citation statements)

References 99 publications

(164 reference statements)

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“…A small number of studies have suggested that some of these symptoms may be reversed by testosterone or estrogen therapy. 28,31 Our criteria for frail health differed from those of Fried et al 6 and from those reported in the St Jude Lifetime Cohort Study. 5 The major limiting factor is that the fifth component of the frailty phenotype, the 'self-reported exhaustion' defined by Fried et al, 6 was missing since questionnaires to classify self-reported exhaustion were not included.…”

Section: Discussionmentioning

confidence: 83%

“…Myeloablative HDTx regimens, irrespectively of the use of TBI, are known to be associated with high-risk gonadal toxicity. 28,29 Many symptoms of hypogonadism are similar to agerelated changes. It may be difficult to conclude if the association of hormonal replacement therapy and frail health indicates simply a more toxic cancer therapy that the survivors have received or an independent effect on frailty.…”

Section: Discussionmentioning

confidence: 99%

“…Eighteen survivors had received local radiotherapy (Supplementary Table 1). The 19 survivors of HR NBL were assessed at a median age of 22 years (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). The median follow-up time after the end of therapy was 20 years (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Treatment Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and biological markers of premature aging after autologous SCT in childhood cancer

Vatanen

Hou

Huang

et al. 2017

Bone Marrow Transplant

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The aim of this study was to analyze the prevalence of frailty and physical health limitations among long-term survivors of high-risk neuroblastoma (HR NBL) and to investigate whether frail health is associated with variables of cardiovascular function, markers of inflammation and telomere length. A national study cohort of 19 (median age 22, range 16-30 years) long-term (>10 years) HR NBL survivors was studied and the findings were compared with 20 age- and sex-matched controls. Frailty was defined as ⩾3 of the following conditions: low muscle mass, low energy expenditure, slow running and weakness. The prevalence of frailty was significantly higher among the HR NBL survivors 9/19 (47%) than among the controls (0%). Thirteen (68%) of the survivors reported significant physical health limitations in vigorous activities, as opposed to none of the controls. The HR NBL survivors had significantly shorter telomere length and higher serum levels of high sensitivity C-reactive protein than did the controls. Frail health and poor physical functioning are prevalent among HR NBL survivors and suggest premature aging. Survivors with gonadal damage, very low fat mass percentage, low glycosylated hemoglobin A1c and increased common carotid artery intima-media thickness may be more prone to early aging after high dose therapy.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Treatment Characteristicsmentioning

confidence: 99%

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Clinical and biological markers of premature aging after autologous SCT in childhood cancer

Vatanen

Hou

Huang

et al. 2017

Bone Marrow Transplant

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“…Some of the studies included in our analysis reported no or minimal side effects after E. longifolia treatment [26,29,30]. This is of interest because TRT, representing the first therapeutic option in the case of hypogonadism, has been associated with the presence of side effects, such as polycythaemia, fluid retention, testicular atrophy, prostate enlargement, congestive heart failure, and obstructive sleep apnea [47]. Furthermore, in males and females, E. longifolia does not negatively affect AST/ALT or body weight, further supporting safe treatment with E. longifolia [48].…”

Section: Discussionmentioning

confidence: 93%

Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials

Leisegang¹,

Finelli

Sikka

et al. 2022

Medicina

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Background and Objectives: Male hypogonadism is a clinical disorder characterized by reduced serum testosterone in men. Although treatment using herbal medicines, including Eurycoma longifolia, has been investigated, the benefits remain unclear. This study aims to investigate the efficacy of E. longifolia as a sole intervention to increase testosterone levels in males. Materials and Methods: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) according to the PRISMA guidelines. Relevant articles were retrieved from the databases PubMed, Scopus, Web of Science, Cochrane, Ovid/Embase, and Google Scholar. Results: After literature screening, a total of nine studies was included in the systematic review. Five RCTs were included in the meta-analysis. A significant improvement in total testosterone levels after E. longifolia treatment was mostly reported in both healthy volunteers and hypogonadal men. The random model effect revealed a significant increase (SMD = 1.352, 95% CI 0.565 to 2.138, p = 0.001) in the total testosterone levels in men receiving E. longifolia supplementation, which was confirmed in the hypogonadism subgroup. Conclusions: This systematic review and meta-analysis of the literature supports the possible use of E. longifolia supplementation for enhancing testosterone production. Although more research is required before its use in clinical practice, this may represent a safe and promising therapeutic option, particularly in hypogonadal men.

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“…İntramusküler preparatların absorbsiyon profilleri farklıdır. Bu nedenle genellikle preparatın çeşidine göre değişen haftalık sürelerde uygulanırlar 22 . Transdermal preparatların günde tek sefer kullanım kolaylığı, uygulama rahatlığı ve daha düşük pik ve düşüşlere yol açma avantajları vardır.…”

Section: Testosteron Replasmanıunclassified

Erişkinde Hipopitüitarizmin Tanı ve Tedavisi

Sisman¹,

Gül

2019

Uludağ Üniversitesi Tıp Fakültesi Dergisi

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Hipopitüitarizm hipofizer ya da hipotalamik hastalıklar nedeniyle ön ve arka hipofiz bez fonksiyonlarında total ya da kısmi kayıp olması ile karakterizedir. Adrenal yetmezlik, hipotiroidizm, hipogonadizm, büyüme hormon eksikliği ve nadiren diyabetes insipidusa neden olur. En sık nedeni hipofiz adenomları ve tedavide uygulanan cerrahi ve radyasyon tedavisinin neden olduğu komplikasyonlardır. Klinik bulgular sıklıkla hormonal eksikliğin şiddeti ile ilişkilidir. Bununla birlikte hipopituitarizm genellikle eşlik eden enfeksiyon ve travma gibi strese yol açabilecek durumlara kadar klinik olarak sessiz seyreder. Artmış morbidite ve mortaliteye yol açması nedeniyle erken tanı ve uygun tedavi önemlidir. Hastalar uzun dönem izlenmeli ve eksik ya da aşırı hormon replasman uygulamalarından kaçınılmalıdır.

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Update on Testosterone Replacement Therapy in Hypogonadal Men

Cited by 6 publications

References 99 publications

Clinical and biological markers of premature aging after autologous SCT in childhood cancer

Clinical and biological markers of premature aging after autologous SCT in childhood cancer

Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials

Erişkinde Hipopitüitarizmin Tanı ve Tedavisi

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