Update on the Bidirectional Link Between Diabetes and Periodontitis

Salhi, Leila; Reners, Michèle

doi:10.1007/978-3-030-96881-6_12

Cited by 16 publications

(13 citation statements)

References 68 publications

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“…DM is a systemic disease with several complications, such as retinopathy, nephropathy, neuropathy, and periodontitis [ 55 ]. Poor glycemic control has been clinically associated with the severity of periodontitis.…”

Section: Chronic Periodontitismentioning

confidence: 99%

Biological Roles of Fibroblasts in Periodontal Diseases

Naruishi

2022

Cells

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Periodontal diseases include periodontitis and gingival overgrowth. Periodontitis is a bacterial infectious disease, and its pathological cascade is regulated by many inflammatory cytokines secreted by immune or tissue cells, such as interleukin-6. In contrast, gingival overgrowth develops as a side effect of specific drugs, such as immunosuppressants, anticonvulsants, and calcium channel blockers. Human gingival fibroblasts (HGFs) are the most abundant cells in gingival connective tissue, and human periodontal ligament fibroblasts (HPLFs) are located between the teeth and alveolar bone. HGFs and HPLFs are both crucial for the remodeling and homeostasis of periodontal tissue, and their roles in the pathogenesis of periodontal diseases have been examined for 25 years. Various responses by HGFs or HPLFs contribute to the progression of periodontal diseases. This review summarizes the biological effects of HGFs and HPLFs on the pathogenesis of periodontal diseases.

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Section: Chronic Periodontitismentioning

confidence: 99%

Biological Roles of Fibroblasts in Periodontal Diseases

Naruishi

2022

Cells

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“…As two major global health threats, diabetes and periodontitis have received a lot of attention in recent years. Growing evidences suggest a bidirectional relationship between these two diseases (Salhi and Reners, 2022). Periodontitis is the sixth most common complication of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Excessive neutrophil extracellular trap formation induced by Porphyromonas gingivalis lipopolysaccharide exacerbates inflammatory responses in high glucose microenvironment

Tong

Yue²,

Fu³

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionNeutrophil extracellular trap (NET) is a novel defense strategy of neutrophils and found to be induced by Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) or high glucose. The aim of this study was to investigate the roles and mechanisms of NET formation in high glucose inflammatory microenvironment.MethodsNETs induced by 1 μg/ml P. gingivalis LPS and/or 25 mM glucose were visualized using a fluorescence microscopy and the levels of extracellular DNA were determined by a microplate reader. The bactericidal efficiency of NETs was assessed by quantifying the survival P. gingivalis in neutrophils. The levels of NLRP3 and IL-1β in THP-1 derived-macrophages, and the expressions of p-PKC βII, p-MEK1/2, p-ERK1/2, ORAI1 and ORAI2 in neutrophils were detected by Western blot. Moreover, levels of intracellular Ca2+ and reactive oxygen species (ROS) in neutrophils were explored by flow cytometry.ResultsP. gingivalis LPS enhanced the formation of NETs and increased the levels of extracellular DNA in high glucose microenvironment (p < 0.05). Compared with normal glucose inflammatory microenvironment, quantities of extra- and intracellular viable P. gingivalis in neutrophils exposed to NETs induced in high glucose inflammatory one were increased (p < 0.05) and the expressions of NLRP3 and IL-1β were dramatically increased in macrophages co-cultured with NETs from high glucose inflammatory microenvironment (p < 0.05). In addition, levels of ROS, intracellular Ca2+, p-PKC βII, p-MEK1/2, p-ERK1/2, ORAI1 and ORAI2 were increased in neutrophils stimulated with both high glucose and P. gingivalis LPS compared with the single stimulus groups (p < 0.05).DiscussionIn high glucose inflammatory microenvironment, formation of NETs was enhanced via oxidative stress, which failed to reverse the decreased bactericidal capacity in high glucose microenvironment, and instead aggravated the subsequent inflammatory responses.

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“…Periodontitis also demonstrates an intimate relationship with other systemic diseases, especially with regard to immune and inflammatory defenses. Among these diseases are diabetes [ 23 ], cardiovascular diseases [ 24 ], rheumatoid arthritis [ 25 ], and metabolic syndrome [ 26 ]. This is an important factor to be considered, since many chronic inflammatory conditions can interact with each other, potentiating the pathological effects of the diseases involved in this process [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Periodontitis in Patients with and without HIV

Pereira

Amorim

Sampaio

et al. 2023

International Journal of Dentistry

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Purpose. The aim of this study was to compare clinical periodontal conditions in HIV-positive people on HAART with an HIV-negative group, in addition to investigating factors associated with periodontitis in the entire sample. Methods. This was a cross-sectional study. Data were collected by oral clinical examination for the diagnosis of periodontitis, review of medical records, and application of a questionnaire containing personal data, deleterious habits, and oral hygiene habits for the other variables. The results were analyzed by Pearson’s χ2 test and Student’s t-test. A logistic regression model was constructed for the multivariate analysis and periodontitis was defined as a dependent variable. The analysis was performed on the entire sample (HIV+ and HIV−) and also on the group consisting of only people living with HIV. Results. Individuals older than 43 years old and with HIV were more likely to develop moderate and severe periodontitis (47.80 and 4.84 times, respectively). When analyzing only HIV+, in addition to age (OR = 2.795; CI = 1.080−7.233), the use of nonnucleoside reverse transcriptase inhibitors (NNRTIs) (OR = 2.841; CI = 1.135−7.112) was also associated with moderate and severe periodontitis. Conclusion. It was possible to observe a higher prevalence of periodontitis among individuals with HIV, showing an association between the virus, advanced age, and moderate or severe periodontitis.

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Update on the Bidirectional Link Between Diabetes and Periodontitis

Cited by 16 publications

References 68 publications

Biological Roles of Fibroblasts in Periodontal Diseases

Biological Roles of Fibroblasts in Periodontal Diseases

Excessive neutrophil extracellular trap formation induced by Porphyromonas gingivalis lipopolysaccharide exacerbates inflammatory responses in high glucose microenvironment

Factors Associated with Periodontitis in Patients with and without HIV

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